10/3/13, Judith Graber, Ph.D., 'Morbidity Among U.S. Coal Miners'
12:00 Noon, Environmental and Occupational Health Sciences Institute, Rutgers University
10/17/13, Tomas Guilarte, Ph.D., Department of Environmental Health Sciences,
Columbia University, Mailman School of Public Health
'Molecular Imaging: The New Frontier in Neurotoxicology', 12 noon, Environmental and Occupational Health Sciences Institute
10/24/13, Jonathan Newmark, M.D., Colonel, US Army, Walter Reed Medical Center
'All you ever wanted to know about chemical warfare agents'
12:00 Noon, 12 noon, Environmental and Occupational Health Sciences Institute
10/31/13, Stephen Burley, M.D, D.Phil.
Distinguished Professor and Director, Center for Integrative Proteomics Research
Rutgers University, 'Structure guided fragment based drug discovery for protein kinase targets',
12 noon, Environmental and Occupational Health Sciences Institute
11/7/13. Ronald Hart, Ph.D., Cell Biology and Neuroscience and Director, Human Genetics Institute of New Jersey Stem Cell Program, Rutgers University
'Induced pluripotent stem cells as models of human genetic diversity and disease'
12 noon, Environmental and Occupational Health Sciences Institute
5/16/12, Frederick Lepore, MD, UMDNJ-Robert Wood Johnson Medical School, “Do my eyes deceive me? False and non-localizing signs in neuro-ophthalmology, 1:30 pm, CAB 1302, New Brunswick, NJ
5/16/12, James R. Marshall, Ph.D., Roswell Park Cancer Institute, “Chemoprevention in lessening the human cost of prostate cancer”, 4:00 pm, CINJ Auditorium, New Brunswick, NJ
5/10/12, Tom Steitz, Yale University, From the structure and function of the ribosome to new antibiotics”, 4:00 pm, UMDNJ-Robert Wood Johnson Medical School, Auditorium, Rutgers University, Busch campus, Piscataway, NJ
5/02/12, Sudipta Roychowdhury, MD, University Radiology Group, “Applications of functional MRI and diffusion tensor imaging”, 1:30 pm, CAB 1302, New Brunswick, NJ
4/26/12 - Drug Metabolism Discussion Group - “Current Topics in DMPK and the New DDI Draft Guidance”
2012 Spring Symposium and Vendor Exhibition
Crowne Plaza Hotel Somerset Bridgewater
110 Davidson Ave.
8:00 a.m. - Registration / Continental Breakfast / Vendor Exhibit
9:00 a.m. - Introductory Remarks, Dr. Lian Zhou, Chair, NJDMDG
9:10 a.m. - ‘Drug Metabolism in Chimeric Mice with Humanized Liver’, Professor Hiroshi Yamazaki, Showa Pharmaceutical University, Machida, Tokyo.
10:00 a.m. - ‘ADME in NAFLD: Genes and Big Jeans Increase the Risk of Adverse Drug Reactions’, Professor Nathan Cherrington, Pharmacology & Toxicology, University of Arizona, Tucson, AZ.
10:45 a.m. - Vendor Exhibit & Coffee Break
11:30 p.m. - ‘Clarity on Transporters: Navigating the New FDA Draft Guidance on Drug Interactions’, Dr. Sid Bhoopathy, Chief Operating Officer, Absorption Systems, Exton, PA.
12:15 p.m. - Lunch & Vendor Exhibit
1 :45 p.m. - ‘The 2012 FDA Draft Guidance on Drug-drug Interactions: Enzyme Induction and Beyond’, Dr. Michael Sinz, Research Fellow, Metabolism and Pharmacokinetics, Bristol-Myers Squibb, Wallingford, CT.
2:30 p.m. - Vendor Exhibit & Coffee Break
3:00 p.m. - ‘Update on the Progress of the IQc/FDA/Academia Collaboration on DDI Prediction and Thoughts on the DDI Draft Guidance’, Dr. Scott Obach, Senior Research Fellow, Pharmacokinetics, Dynamics, and Drug Metabolism Department, Pfizer, Groton, CT.
3:45 p.m. - Program Closure
4/25/12, Zena Werb, Ph.D., University of California, San Francisco, “Of mice and women: How studying mammary development gives us Insights into breast cancer”, CINJ Auditorium, New Brunswick, NJ
4/18/12, Xiaowei Zhuang, Harvard University, “Bioimaging at the nanoscale: Single-molecule and super-resolution fluorescence microscopy, 12:00 pm, CABM 010, Rutgers University, Busch campus, Piscataway, NJ
4/06/12, Indrajit Ghosh, "Design and evaluation of special drug delivery techniques of poorly soluble drugs for enhancing skin permeability”, Pharmaceutical Sciences, seminar room, 10:00 am, School of Pharmacy, Rutgers University, Piscataway, NJ
4/05/12, Qiang Zhang, “Regulation of drug transporters”, Pharmaceutical Sciences, seminar room, 10:00 am, School of Pharmacy, Rutgers University, Piscataway, NJ
4/05/12, Dr. Kirsten Hagstrom, University of Massachusetts Medical School, "Condensin proteins are required to silence transcription during RNA interference" 12:00 pm, Waksman 010, Rutgers University, Busch campus, Piscataway, NJ
4/04/12, Stephen Wong, MD, UMDNJ/RWJMS, “ Non-pharmacologic Treatment Options in Epilepsy”, 1:30, MEB 102, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ
4/03/12, Matt Lord, Ph.D., University of Vermont, “Bar-coding of the actin track and myosin motor function in the cell”, 12:00 pm, CABM 010, Rutgers University, Busch campus, Piscataway, NJ
3/28/12, Dermatology Forum: Introduction to Developing Skin Products, Life Sciences Building seminar room, Rutgers University Busch campus, Piscataway, NJ
Drs. Joel Zatz, Rutgers University and Dr. Otto Mills, UMDNJ-Robert Wood Johnson Medical School
8:20 am Introduction to Developing Skin Products
8:30 am From the Top Down
9:15 am Skin Delivery and Delivery Systems
10:00 am Break
10:15 am Formulations-Critical Components of Skin Product Formulations-Steinberg
11:00 am The Changing Regulatory Landscape
11:45 am Lunch
12:30 pm Human Safety & Efficacy Testing
1:15 pm Acne to Xerosis-Changing Paradigms
2:00 pm Panel Discussion and Questions-Current Challenges in Skin Product Development
3/26/12, Dr. Edward R. Dougherty, Dept. of Electrical and Computer Engineering, Texas A M University, College Station, "Design of molecularly targeted drugs in the context of gene regulatory pathways", Life Sciences Building seminar room, Rutgers University Busch campus, Piscataway, NJ
Translational drug development uses biological knowledge, in particular, regulatory pathways, to test and design drugs. This talk describes three levels of design currently under investigation. The first uses time-course measurements of green fluorescent protein (GFP) reporters to identity the effect of cancer drugs on regulatory pathways. The technology measures GFP intensity for individual genes in individual cells to obtain quantification of population dynamics that reveal alterations in pathway logic induced by drug intervention. The second level of design assumes that the regulatory effects of a collection of drugs are well-known, transforms pathway representation into logical circuitry, and uses logical calculus to determine minimally complex effective drug combinations. Finally, assuming a full regulatory description in the form of a probabilistic Boolean network, the talk addresses optimal structural intervention. In this case the desire is to find the structural (logical) alteration to the wiring (regulatory logic) that maximally diminishes the long-run probability of entering undesirable (cancerous) states.
3/20/12, Symposium: “Frontiers in Lipidomics – The Food, Nutrition and Health Connection”, 9:00 am-4:00 pm, Cook Campus Center, Cook College, Rutgers Univesity, Piscataway, NJ
Lipidomics, the study of a broad range of lipids in the context of a biological system, has exploded in interest within the last few years, due in part to the rapid development of analytical tools such as mass spectrometry. This symposium will highlight the use of mass spectrometry-based lipidomics to answer nutrition and health-related questions, and will address the directions in which lipidomics is moving.
Peter Gillies, Ph.D., New Jersey Institute for Food, Nutrition and Health, Rutgers University
The Transition From Lipid Analysis to Lipidomics
Joseph Dixon, Ph.D., Dept. of Nutritional Sciences, Rutgers University
The Macrophage and Plasma Lipidomes in Health, Nutrition and Disease
Edward Dennis, Ph.D., Dept. of Chemistry and Biochemistry and Dept. of Pharmacology, University of California, San Diego.
Targeted Lipidomic Profiling: A Powerful Nutritional Phenotyping Tool
John Newman, Ph.D., USDA/ARS, Western Human Nutrition Research Center and Dept. of Nutrition, University of California, Davis
Unbiased Analysis of Biological Samples for Lipids and Small Molecule Metabolites
Serhiy Hnatyshyn, Ph.D., Senior Research Scientist, Bristol-Myers Squibb
What's On the Horizon for Lipidomics
Paul Baker, Ph.D., Lipid Specialist, ABSciex
George Carman, Ph.D., Dept. of Food Science and Rutgers Center for Lipid Research, Rutgers University
2/8/12, Dr. Yinzhi Lai, University of Georgia, “Neural microtissue engineering for high throughput screening in pre-clinical drug discovery”, 12:00 pm, Life Sciences Building seminar room, Rutgers University Busch campus, Piscataway, NJ
Cells cultured in three dimensional (3D) scaffolds as opposed to traditional two-dimensional (2D) substrates have been considered more physiologically relevant based on their superior ability to emulate the in vivo environment. Combined with stem cell technology, 3D cell cultures can provide a promising alternative for use in cell-based assays or biosensors in pre-clinical drug discovery studies. In this study, a 3D cell-based assay platform was established by integrating 3D synthetic polymer scaffolds with standard cell culture dishes and multi-well plates. A transcriptomic expression comparison among neural progenitor cells cultured on 2D substrates, 3D porous polystyrene scaffolds, and as 3D neurospheres (in vivo surrogate) was conducted. Results showed that unlike the NS cells cultured on traditional 2D planar surfaces, cells in 3D scaffolds are more physiologically relevant with respect to in vivo characteristics exhibited by in vivo surrogates such as neural spheres and freshly dissected superior cervical ganglian. Up-regulation of cytokines as a group in 3D and neurospheres was observed. A group of 13 cytokines were commonly up-regulated in cells cultured in polystyrene scaffolds and neurospheres, suggesting potential for any or a combination from this list to serve as three-dimensionality biomarkers. Our new biomimetic cell-based assay platform may provide a broadly applicable 3D cell-based system for use in drug discovery programs and other research fields.
2/6/12, Dr. Lawrence P. Wennogle, Intra-Cellular Therapies, Inc., NYC, "A Novel Target for Alzheimer’s Disease Therapies – Gamma-Secretase Activating Protein (GSAP)",12:00 pm, Life Sciences Building seminar room, Rutgers University Busch campus, Piscataway, NJ
Substantial human genetic evidence supports the accumulation of neurotoxic ß-amyloid (Aß) as a major causative feature of Alzheimer’s disease (AD). Formation of Aß is catalyzed by ?-secretase, a protease with numerous substrates, but the molecular mechanisms involved in substrate specificity of this promiscuous enzyme are insufficiently understood. Our goal is to identify and develop clinically effective agents that can reduce Aß formation without undesirable side effects. We have reported the discovery of ?-secretase activating protein (GSAP), a novel target for the development of AD therapies. This protein selectively increases Aß production by virtue of interactions with both ?-secretase and its substrate, the amyloid precursor protein. GSAP stimulates Aß production in vitro and in intact cells. Knockdown of GSAP in a mouse model of Alzheimer’s disease reduces levels of Aß and plaque development. These discoveries have revealed GSAP as a ?-secretase regulator that directs ?-secretase enzyme specificity. We continue to elaborate the signaling systems surrounding GSAP and have discovered novel Aß lowering agents based upon this mechanism.
1/23/12, Jeffrey D. Laskin, Ph.D., UMDNJ-Robert Wood Johnson Medical School, CDR Seminar Series, "Structural Changes in the Skin During Chemical Induced Inflammation and DNA Damage", 5:00 pm, Life Sciences Building seminar room, Rutgers University Busch campus, Piscataway, NJ
11/14/11, Dr. Larry Wennogle, Intra-Cellular Therapies, Inc., NY, "Drug discovery for Alzheimer disease", 12 noon, Human Genetics Institute-Auditorium, Life Sciences Building, 145 Bevier Road, Rutgers University, Busch Campus, Piscataway, NJ
11/14/11, Dr. Marion Gordon, Pharmacology and Toxicology, Rutgers School of Pharmacy, Ocular Effects of Sulfur Mustard on the Cornea”, 4 pm, EOHSI rooms A&B, Rutgers University, Piscataway, NJ
11/2/11, Dr. Mark S. Freedman, University of Ottawa, “Bone Marrow Transplantation in Multiple Sclerosis” 1:30 pm, Clinical Academic building, room 1302, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ
10/18/11, Dr. Gianluigi Veglia, University of Minnesota, "Structural Analysis of Calcium Regulation in Muscle by NMR Spectroscopy: from Understanding to Control", 11 am, Wright Rieman Auditorium, Chemistry Building, Rutgers University, Piscataway, NJ
Calcium homeostasis is central to excitation-contraction coupling in muscle. In this talk, I will focus on the structural analysis of a membrane protein complex between the sarcoplasmic reticulum Ca2+-ATPase (SERCA) and phospholamban (PLN), which is responsible for approximately 70% of the Ca2+ reuptake into the sarcoplasmic reticulum membrane, thereby controlling the relaxation phase of muscle. Using a combination of NMR methods, we mapped the conformational transitions of PLN free and bound to SERCA. I will illustrate how PLN conformational dynamics (i.e molecular motions) play a key role in the regulatory cycle of SERCA. Finally, I will demonstrate that by tuning the flexibility of PLN, it is possible to modulate the activity of SERCA. The latter represents a possible avenue for protein therapy designed to ameliorate muscle diseases and cardiomyopathy.
10/12-10/13/11, "Skin Reconstruction for Wounds, Burns, and Deep Skin Trauma", Center for Dermal Research, Busch Campus, Rutgers University, Piscataway, NJ. To register, send an email here.
B. Lynn Allen-Hoffmann, Ph.D., Professor of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, "Human Skin Substitutes: Extracellular Matrices and Biomarkers."
Stephen Boyce Ph.D. Research Associate Professor, University of Cincinnati, College of Medicine, Cincinnati, "Burn Repair with Engineered Skin Substitutes."
Connie Lin, Ph.D. R. Ph., Senior Research Fellow, Johnson & Johnson Skin Research Center, Skillman NJ. "In vitro Models for the Evaluation of Skin Care Agents and Formulations."
Industrial panelists from Johnson & Johnson, Advanced BioHealing, Lonza and Integra that are commercializing or working with skin regeneration products.
After-Dinner Speaker: Joachim Kohn, Ph.D. Director of Rutgers-Cleveland Clinic Consortium of the Armed Forces Institute for Regenerative Medicine (AFIRM), "The Promise of Tissue Engineering and Regenerative Medicine to Victims of Severe Trauma."
Adam Katz, M.D. Associate Professor of Plastic Surgery and Biomedical Engineering, Dept. of Plastic and Maxillofacial Surgery, Charlottesville, VA, "Clinical Trial: Fat Grafting for Scar Remodeling and Management."
Richard Clark, M.D., Biomedical Engineering SUNY Stony Brook, "Advanced Approaches for Managing Burn Wounds."
James Hill Holmes IV, M.D. Wake Forest University Baptist Medical Center, Institute for Regenerative Medicine, Wake Forest, NC, "Burns, Trauma and Surgical Critical Care."
Robert Christy, Ph.D., Extremity Trauma Research, U.S. Army Institute of Surgical Research, Fort Sam Houston, TX 78234-6315,
FDA speaker to cover issues with approval of skin regeneration products and drug delivery formulations
10/12/11, Pengbo Zhou, Ph.D., Weill Cornell Medical College, “Ubiquitin-proteolytic Control of DNA Repair and Carcinogenesis” 4 pm, Cancer Institute of New Jersey, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ
10/5/11, Chen-Yong Lin, Ph.D., University of Maryland, “Matriptase-mediated Cell Surface Proteolysis: Regulation and Strategy for Functional Suppression” 4 pm, Cancer Institute of New Jersey, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ
10/3/11, Dr. Hana Aviv, "Topics in cytogenetics of hematological malignancies", Department of Pathology, Robert Wood Johnson Medical School, New Brunswick, 12 noon, Human Genetics Institute-Auditorium, Life Sciences Building, 145 Bevier Road, Rutgers University, Busch Campus, Piscataway, NJ
9/26/11, Dr. Joseph R. Landolph, University of Southern California, "Nickel-Induced Global Disruption of Gene Expression Results in Morphological/Neoplastic Transformation of C3H/10T1/2 Mouse Embryo Cells", 12 noon, Human Genetics Institute-Auditorium, Life Sciences Building, 145 Bevier Road, Rutgers University, Busch Campus, Piscataway, NJ
9/20/11, Hank F. Kung, Ph.D., Univerrsity of Pennsylvania, “PET Imaging Agents for Studying Neurodegenerative Disease”, 12 noon, Room 323A, Rutgers University School of Pharmacy, Piscataway, NJ
9/14/11, Andrea DeSantis Rodrigues, Pharmacology and Toxicology, Rutgers University, “Countermeasures Against Vesicant-Induced Corneal Epithelial De-Adhesion”, 12 noon, EOHSI building, Busch campus, Rutgers University, Piscataway, NJ
5/24/11, 8:00 am-3:30 pm, "Developing Skin Products, an overview of pharmaceutics and skin care” a symposium for researchers, product developers, and evaluators of skin products
From the Top Down: Aspects of product quality/ formulation goals
Skin Delivery and Delivery Systems: Definitions and overview of methods/delivery systems and their properties
Critical Components of Skin Products: Preservation and preservatives/sunscreens
The Changing Regulatory Landscape: Regulatory considerations in product development /global influences and harmonization/recent developments and emerging trends
Human Safety & Efficacy Testing: Clinical and non-invasive evaluations/plans and protocols
Acne to Xerosis-Changing Paradigms: Common chronic disorders/diseases/approaches for research and products
Panel Discussion with Presentors:
Joel L. Zatz Ph D, Professor Emeritus at Rutgers University, has taught graduate and undergraduate courses in surface chemistry, pharmacokinetics, skin delivery, and the technology of liquid and semisolid topical delivery systems. For the past 25 years he has participated in training programs for FDA inspectors. His areas of research interest include skin delivery of drugs, preservatives and provitamins; skin technology of disperse systems; and penetration of antifungals through human nail. He is the author of Pharmaceutical Calculations, a textbook now in its 4th edition and editor of Skin Permeation, published by Allured. He is a member of the editorial board of the Journal of Pharmaceutical Sciences and editor of the Journal of Cosmetic Science.
David C. Steinberg has over 35 years experience in the cosmetic industry and specializes in cosmetic regulations, labeling, preservation and sunscreens. He founded the Masters Degree program in Cosmetic Sciences at Fairleigh Dickenson University and taught there from 1982 to 2000. He is a member of the American Chemical Society, Society of Cosmetic Scientists, Institute of Food Technologists, Regulatory Affairs Professional Society and is a Fellow member of the Society of Cosmetic Chemists. He has written 4 books including Preservatives for Cosmetics, The Guide to the European Cosmetic Regulations and has authored many papers and chapters in books.
Otto H. Mills Jr., PhD, F.C.P. is an Adjunct Professor, Department of Dermatology, University of Medicine and Dentistry of New Jersey - Robert Wood Johnson Medical School. He has lectured at universities and medical meetings in the United States, Europe and Asia and authored or co-authored over two hundred publications. Dr. Mills has served as the Chair of Dermatologic and Allergic Diseases, American Society of Clinical Pharmacology and Therapeutics, and is a Fellow of the American College of Clinical Pharmacology.
5/5/11, 4:00 pm, Gerald N. Wogan, Ph.D., Department of Biological Engineering, Massachusetts Institute of Technology, “DNA damage and genetic alterations in carcinogenesis”, EOHSI conference room C, Busch campus, Piscataway, NJ
4/28/11, 12:00 pm, Norbert Kaminski, Ph.D., Professor, Integrative Toxicology, Michigan State University, “The B lymphocyte as a cellular target for immunotoxicity by 2,3,7,8 - tetrachlorodibenzo-p-dioxin. A tale of mice and men”, EOHSI conference room C, Busch campus, Piscataway, NJ
4/20/11; Nahum Sonenberg McGill University, Montreal, Canada, " Translational Control of Cancer", CABM 010, 12:00 pm.
4/14/11, 12:00 pm, Aaron Bowman, Ph.D., Department of Neurology, Vanderbilt University, “Analysis of disease-toxicant interactions in Huntington's Disease and Parkinson's Disease”, EOHSI conference room C, Busch campus, Piscataway, NJ
4/14/11, 12 pm, Stephen H Wright, Ph.D., University of Arizona, “Structure and Function of Human Multidrug and Toxin Extruders”; Laboratory for Cancer Research Room 202; School of Pharmacy, Rutgers University, Busch campus, Piscataway, NJ
4/13/11, 12 pm, Deanna Kroetz, Ph.D., Biopharmaceutical Sciences, UCSF, “Functional and Clinical Implications of Membrane Transporter Polymorphisms”, Laboratory for Cancer Research Room 202; School of Pharmacy, Rutgers University, Busch campus, Piscataway, NJ
4/12/11 - Advances in Imaging and Genomics - 3rd Annual UMDNJ Inter-School Technology Symposium, RWJMS, Piscataway, NJ.
8:15 am - Registration and Continental Breakfast
9:00 am - Welcome and Overview, Denise V. Rodgers, M.D., Executive Vice President for Academic and Clinical Affairs, UMDNJ
9:10 am - Comments from the New Jersey Bi-Partisan Assembly Life Sciences Task Force. Introduction by Kathleen W. Scotton, Ph.D., Vice President for Research, UMDNJ
9:30 am - AM Keynote Address, Barbara Alving, M.D., Director, NIH National Center for Research Resources, "Creating Public/Private Partnerships to Advance Research Technologies for the Public Good"
10:30 am - Break
10:45 am - Morning Track Sessions (Concurrent)
Track 1: Advances in Imaging Technologies for Biomedical Research Moderator: William C. Gause, Ph.D., Senior Associate Dean for Research; University Professor of Medicine, UMDNJ-New Jersey Medical School (NJMS)
Speaker 1: Sanjay Tyagi, Ph.D. Associate Professor, Dept. of Medicine; Member, Public Health Research Institute (PHRI), UMDNJ-New Jersey Medical School (NJMS) “Imaging Single mRNA Molecules in Live Cells”
Speaker 2: Scott Kachlany, Ph.D. Associate Professor, Dept. of Oral Biology, UMDNJ-New Jersey Dental School (NJDS) "Visualizing anti-leukemia activity of a natural bacterial toxin using in vivo animal imaging"
Speaker 3: Eugene Tunik, PT, PhD, Assistant Professor, Director, Laboratory for Movement Neuroscience, Department of Rehabilitation and Movement Science, UMDNJ-School of Health Related Professions (SHRP) "Characterizing human neuroplasticity after stroke with integrated motion capture, virtual reality, and functional MRI, and Transcranial Magnetic Stimulation"
Track 2: Advances in Genomics and Diagnostics Moderator: Robert Denmark, Ph.D., Associate Dean for Research (Interim); Associate Professor, Dept. of Interdisciplinary Studies, UMDNJ-School of Health Related Professions (SHRP)
Speaker 1: Gunaretnam Rajagopal, Ph.D. Executive Director of Bioinformatics, Cancer Institute of New Jersey, UMDNJ-Robert Wood Johnson Medical School (RWJMS) " Bioinformatic tools for next generation genomics data analysis”
Speaker 2: William Welsh, Ph.D. Professor, Dept. of Pharmacology; Director, Informatics Institute, UMDNJ-Robert Wood Johnson Medical School (RWJMS) "E-Prospector Technology Platform to Accelerate Translational Research and Pharmaceutical Drug Discovery".
Speaker 3: Peter Tolias, Ph.D. Professor, of Pediatrics; Executive Director, The Institute of Genomic Medicine, UMDNJ-New Jersey Medical School (NJMS) “Genomic Technologies used In Molecular Diagnostics” 12:00 Noon LUNCH
12:00 pm - Lunch
1:00 pm - PM Keynote Address, Heidi Rehm, Ph.d., FACMG, Director, Harvard Laboratory for Molecular Medicine at Partners Healthcare Center for Personalized Genetic Medicine "Delivering Genomic Medicine: Challenges and Opportunities"
2:15 pm - Afternoon Track Sessions (Concurrent)
Track 1: Advances in Imaging Technologies for Biomedical Research
Moderator: Terri Gross-Kinzy, Ph.D., Senior Associate Dean for Research; Professor, Dept. of Molecular Genetics, Microbiology and Immunology, UMDNJ-Robert Wood Johnson Medical School (RWJMS)
Speaker 1: Dennis P. Carmody, Ph.D. Professor, Dept. of Pediatrics, UMDNJ-Robert Wood Johnson Medical School (RWJMS) “Functional Magnetic Resonance Imaging of Adolescents Exposed Prenatally to Drugs”
Speaker 2: Lawrence D. Gaspers, Ph.D. Associate Professor, Dept. of Pharmacology and Physiology, UMDNJ-New Jersey Medical School (NJMS) “The use of fluorescent biosensors to measure mitochondrial function and redox homeostasis in animal models of disease”
Speaker 3: Noah Weisleder, Ph.D. Assistant Professor, Dept. of Physiology and Biophysics, UMDNJ-Robert Wood Johnson Medical School (RWJMS) “Live Cell Imaging of Cell Membrane Repair: from Basic Discovery to Therapeutic Application”
Track 2: Advances in Genomics and Diagnostics Moderator: Daniel Fine, Ph.D., Professor, Dept. of Oral Biology; Director, Center for Oral Infectious Diseases, UMDNJ-New Jersey Dental School (NJDS)
Speaker 1: David Alland, M.D. Professor and Division Chief, Dept of Medicine, Division of Infectious Disease; Director (Interim) Ruy D. Lourenco Center for Emerging and Re-Emerging Pathogens, UMDNJ-New Jersey Medical School (NJMS) “Translating DNA sequence results to near-patient diagnostic tests”
Speaker 2: Bin Tian, Ph.D. Associate Professor, Dept. of Biochemistry and Molecular Biology; Director, Center for Genome Informatics, UMDNJ-New Jersey Medical School (NJMS) “Deep understanding of post-transcriptional gene regulation by next-generation sequencing”
Speaker 3: Scott Diehl, Ph.D. Professor, Dept. of Oral Biology; Director, Center for Pharmacogenomics and Complex Disease Research, UMDNJ-New Jersey Dental School (NJDS) "Leveraging Human Genomic Technologies to Accelerate Translation to the Clinic"
3:30 pm - Networking, poster sessions, and vendor show
5:00 pm - Adjournment
4/7/11, 12:00 pm, Paul Lioy, Ph.D., Professor and Division Director, Exposure Science Division, EOHSI, “Exposure science and toxicology: collaboration within the ‘exposome’ framework”, EOHSI conference room C, Busch campus, Piscataway, NJ
4/4/11, Celeste Nelson, Ph.D., Princeton University, “Morphogenesis of engineered epithelial trees”, 1:30-2:30 pm, room BME-102, Biomedical Engineering Building, Busch campus, Piscataway, NJ
3/31/11, 12:00 pm, Glenn Wilson, Ph.D., University of S. Alabama College of Medicine, “The use of DNA repair proteins targeted to mitochondria to alter disease”, EOHSI conference room C, Busch campus, Piscataway, NJ
3/28/11, Herb Geller, Ph.D., National Heart, Lung, and Blood Institute, NIH, “Understanding and overcoming the glial scar: improving regeneration after CNS injury”, 1:30-2:30 pm, room BME-102, Biomedical Engineering Building, Busch campus, Piscataway, NJ
3/24/11, 12:00 pm, John P. Vanden Heuvel, Ph.D., Penn State University, “Regulation of gene expression by dietary fatty acids”, EOHSI conference room C, Busch campus, Piscataway, NJ
3/7/11, Xiaolong Luo, Ph.D., University of Maryland, “Biofabrication: Interfacing Biology with Microfluidics”, 1:30-2:30 pm, room BME-102, Biomedical Engineering Building, Busch campus, Piscataway, NJ
3/7/11-3/10/11 - UMDNJ/Rutgers University CounterACT Research Center of Excellence presentations at the 50th Anniversary Annual Meeting of the Society of Toxicology in Washington, DC
3/8/11 - Platform Presentation - Chemical and Biological Weapons - Sulfur Mustard Effects - 1:30-4:15pm, Room 145 Convention Center
1:49-2:08 pm - 1749. Induction of autophagy in a mouse keratinocyte construct model by the vesicant 2-chloroethyl ethyl sulfide; regulation by MAP kinases and caveolae. A. T. Black; R. P. Casillas; D. E. Heck; D. R. Gerecke; D. L. Laskin; J. D. Laskin
2:08-2:27 pm - 1750. Role of caveolae in regulating expression of Hsp27 and Hsp70 following exposure of human and mouse skin models to the vesicant 2-chloroethyl ethyl sulfide. J. D. Laskin; A. T. Black; P. J. Hayden; R. P. Casillas; D. E. Heck; D. R. Gerecke; D. L. Laskin
2:27-2:45 pm - 1751. Sulfur mustard vapors induce DNA damage and apoptosis in mouse skin L. B. Joseph; D. R. Gerecke; A. T. Black; R. P. Casillas; N. D. Heindel; P. J. Sinko; D. E. Heck; D. L. Laskin; J. D. Laskin
2:45-3:03 pm - 1752. Mechanisms of vesicant-induced cytotoxicity in lung epithelial cells Y. Wang; D. E. Heck; D. L. Laskin; J. D. Laskin
3/9/11 - Poster Session - Chemical and Biological Weapons - 9:00-12:30 pm, Exhibit Hall
2026 Poster Board -617. The Hairless Mouse Back Model and the MEVM Have Similar Molecular Profiles J. D. Wang; M. Soriano; N. Singer; R. P. Casillas; D. R. Gerecke; Y. Chang
2028 Poster Board -619. Role of endogenous cannabinoids in vesicant-induced skin injury I. M. Wohlman; D. E. Heck; N. D. Heindel; M. Huang; D. R. Gerecke; P. J. Sinko; C. J. Lacey; D. L. Laskin; J. D. Laskin
2030 Poster Board -621. Cell survival and apoptosis markers in sulfur mustard exposed mouse skin Y. Chang; J. D. Wang; R. P. Casillas; M. K. Gordon; D. R. Gerecke
2031 Poster Board -622. Sulfur Mustard Exposure of the Cornea Induces Autophagy L. Raman; R. A. Hahn; J. J. Schlager; R. Gordon; D. R. Gerecke; M. C. Babin; M. K. Gordon
2032 Poster Board -623. Nitrogen Mustard-Induced Corneal Injury is Ameliorated by ADAM17/TACE Inhibitors A. S. DeSantis; R. A. Hahn; N. D. Heindel; K. K. Svoboda; D. R. Gerecke; M. K. Gordon
2033 Poster Board -624. Comparison of Corneal Wound healing after Ultraviolet and Nitrogen Mustard Injury I. P. Po; A. S. DeSantis; R. A. Hahn; D. R. Gerecke; J. D. Laskin; M. K. Gordon
3/3/11, Symposium: Center for Dermal Research, Rutgers University, Life Sciences Building, Rutgers University, Piscataway, NJ.
Angela Christiano, Ph.D., Columbia University, “Differentiation of human iPS cells into keratinocytes”
Kishore Shah, Ph.D., Polytherapeutics, “Novel dermal and transdermal drug delivery systems”
3/2/11, Geoffrey Shapiro, M.D., Ph.D., Dana-Farber Cancer Institute, “Cyclin-Dependent Kinases as Targets for Cancer Treatment, 4:00-5:00 pm, CINJ Auditorium, New Brunswick, NJ
2/28/11, Ernest Feleppa, Ph.D., Riverside Research Institute, New York, “Quantitative Ultrasound for Imaging Tissues: Applications to Diagnosis & Treatment of Disease”, 1:30-2:30 pm, room BME-102, Biomedical Engineering Building, Busch campus, Piscataway, NJ
2/24/11, Jun Song, Ph.D., UC San Francisco, “Incomplete DNA Methylation and Somatic Cell Memory in Human iPS Cells”, 1:30-2:30, Hill Center, Busch Rm 260 Busch Campus, Rutgers University, Piscataway, NJ
2/17/11, 12:00 pm, Yana Bromberg, Ph.D., Department of Biochemistry and Microbiology, Rutgers University, “Identifying protein functional sites using in silico mutagenesis”, EOHSI conference room C, Busch campus, Piscataway, NJ
2/16/11, Shweta Urva, Ph.D., Novartis Pharmaceuticals, “Antibody mediated targeting for the treatment of colorectal cancer”, 12:00 pm-1:00 pm, room 111, School of Pharmacy, Busch campus, Rutgers University
2/16/11, Wei Chen, Ph.D., University of Michigan, “Statistical Methods and Analysis for Genome-wide Association Studies and Next Generation Sequencing”, 12:00 pm-1:00 pm, Auditorium, Life Science Building, Busch Campus, Piscataway, NJ.
2/14/11, Jill Wildonger, Ph.D., University of California San Francisco, "Building unique cellular compartments: the role of dynein in neuronal morphogenesis", 4:00 pm-5:00 pm, Auditorium, Life Science Building, Busch Campus, Piscataway, NJ.
2/14/11, David Mark Welch, Ph.D., of Josephine Bay Paul Center for Comparitive Molecular Biology & Evolution, Marine Biological Laboratory, "Evolution of Genome Architectures", 12:00 pm-1:00 pm, Auditorium, Life Science Building, Busch Campus, Piscataway, NJ.
2/11/11, Dr. Alexei Tkachenko, Brookhaven National Laboratory, “Nanoparticles with DNA-mediated interactions: from mess to order and complexity”, 12:30 pm-1:30 pm, E287, Serin Physics Laboratory, Busch Campus, Piscataway, NJ.
2/10/11, Dr. Andrew Kern, Dartmouth College, “The tortoise and the hare: finding the targets of natural selections in genomes”, 12:00 pm-1:00 pm, Auditorium, Life Science Building, Busch Campus, Piscataway, NJ.
2/9/11, Dr. Vladimir Privman, Clarkson University, “Information Processing with Biomolecules: Unconventional Computing Paradigms, Biocoputing, and Enzyme Reaction Kinetics”, 1:30 pm-2:30 pm260 Hill Center, Busch Campus, Piscataway, NJ.
2/7/11, Ravi Birla, Ph.D., “Models for 3-Dimensional Cardiovascular Tissue Constructs”, 1:30-2:30 pm, room BME-102, Biomedical Engineering Building, Busch campus, Piscataway, NJ.
2/7/11, Dr. Howard Passmore, Rutgers University, “Charles Darwin, Early Thoughts on Species Change and Natural Selection”, 12:00 pm-1:00 pm, Auditorium, Life Sciences, Busch Campus.
1/31/11, Joachim Kohn, Ph.D., Rutgers University Center for Biomaterials, “The Promise of Tissue Engineering”, 1:30-2:30 pm, room BME-102, Biomedical Engineering Building, Busch campus, Piscataway, NJ
1/19/11; Basil Rigas, M.D., D.Sc. Stony Brook School of Medicine, " Modified NSAIDs for the Control of Cancer", CINJ Auditorium, 4:00 pm.
1/13/11; Dr. Lee Dicker, Rutgers University, “Increased Power for the Analysis of Label-Free LC-MS Data by Combining Spectral Counts and Peptide Peak Attributes”, 1:30 pm-2:30 pm, 260 , Hill Center , Busch Campus, Rutgers University
12/16/10, Dr. Jinchuan Xing, Dept. of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT, “Human Genomic Variation: hunting disease gene, and understanding mobile DNA elements". 11:00 am, Life Sciences Bldg conference room, Piscataway, NJ
In this talk, I will first describe a new disease-gene finding program (VAAST) that is capable of automated identification of disease-causing genes using personal genome sequences. Then, I will describe a high-throughput method for mobile DNA element identification (ME Scan) and how to apply it to obtain insights on mobile element biology.
12/13/10 - Recent Advances Towards an HIV Vaccine: Understanding the Protective Humoral Response Towards HIV. UMDNJ-New Jersey Medical School, ICPH Building 225 Warren Street, Newark, NJ.
Chair, Abraham Pinter, Ph.D., UMDNJ-New Jersey Medical School
2:00 -2:40 PM
Joseph Sodroski, M.D., Dana-Farber Cancer Institute
“The HIV-1 Envelope Glycoproteins: Structure and Function”
George Shaw, M.D., Ph.D., University of Alabama at Birmingham
“Transmitted/founder Viruses in Acute HIV, SIV and HCV Infection: A Genetic Approach for Elucidating Microbial Transmission and Pathogenesis”
Chair, Patricia Fitzgerald-Bocarsly, Ph.D.
New Jersey Medical School-UMDNJ
Patricia Fitzgerald-Bocarsly, UMDNJ-New Jersey Medical School
Gary J. Nabel, M.D., Ph.D, National Institutes of Health
“The Road to a Neutralizing Antibody-based AIDS Vaccine"
Sanjay Phogat, Ph.D., International AIDS Vaccine Initiative
“Novel HIV-1 Broad Neutralizing Antibodies and Their Role in Vaccine Design”
5:20- 6:00 PM
Robert J. O’Connell, M.D., Walter Reed Army Institute of Research
“Thai Phase III HIV Vaccine Trial: New Science and Next Steps”
12/10/10, Patrick Sinko, Ph.D., Professor of Pharmaceutics, Rutgers University, “Dual Active-Passive Targeting Approach for Minimizing Lung Cancer Metastases" 1:30 pm, UMDNJ-Robert Wood Johnson Research Tower, 4th floor Pharmacology conference room, Piscataway, NJ.
12/8/10; Timothy C. Thompson, Ph.D., M.D. Anderson Cancer Center, " GLIPR1- a Novel Tumor Suppressor Protein and Potential Therapeutic Agent", CINJ Auditorium, 4:00 pm.
12/6/10; Dr. Lisa Denzin, Sloan-Kettering Cancer Institute, "Autoimmune Disease", Life Sciences building, Busch campus, Piscataway, NJ, 11:00 am.
11/23/10; Dr. Eric Lai, Memorial Sloan Kettering Cancer Center, "Biogenesis and function of small regulatory RNAs", CABM 010, 12:00 pm.
11/17/10; Dr. Hua Lu, Indiana Universiaty School of Medicine, "The p53-MDM2-MDMX Pathway: from cancer mechanisms to drug discovery", 4:00 pm, Cancer Institute of New Jersey, Auditorium.
11/12/10; Gregoire Altan-Bonnet, Ph.D., "Single-cell quantification of IL-2 response by effector and regulatory T cells reveals a highly-dynamic cytokine tug-of- war and a critical plasticity in immune response", 12:00 pm, B228, Nelson Labs, Busch campus
11/11/10, Dr. Tim B. Schedl, Washington University - St. Louis, “Intersection of germline mitotic cell cycle regulation & the decision to initiate meiotic development in C. elegans”; 12:00 noon, CABM 010, Busch campus, Rutgers University
11/10/10; Carlo Croce, M.D., Ohio State University, "Causes and Consequences of microRNA Dysregulation in Cancer", CINJ Auditorium, 4:00 pm.
11/8/10, Alexandre David, Ph.D., "NIAID Journey to the Center of Translation: In = Situ Visualization of Compartmentalized Active Translation Sites", 12:30 pm, R-123 Dean's Conference Room, RWJ-Piscataway campus.
11/4/10, Dr. Stephen Martin, University of Texas at Austin, “Recent Advances in the Synthesis of Complex Heterocyclic Natural Products”, 11:00 am, Wright Chemistry Bldg, Busch campus, Rutgers University.
11/2/10, Epigenetics: Toxic Responses and Diseases, Fall meeting of the Mid-Atlantic Society of Toxicology, Rutgers EcoComplex, 1200 Florence-Columbus Road, Bordentown, NJ 08505
8:00-9:00 - Registration/Continental Breakfast
9:00-9:15 - Welcome and MASOT update - Dr. Ken Reuhl
Program Introduction - Dr. Ray York
9:15-10:00 - Dr. Randy Jirtle (Duke University)
Title: 'Epigenetics and toxicology in the 21st century'
10:00-10:45 Dr.Karen Armstrong (Bristol-Myers Squibb)
Title: 'Epigenetic change: current state of the science and perspectives on future applications to safety assessment'
10:45-11:05 - Break
11:05 – 11:50 Dr. Delores Lamb (Baylor College of Medicine)
Title: ‘Genetics/epigenetics: Towards a personalized solution for medicine’
11:50 – 1:45 Lunch
1:45-2:30 Dr. Max Costa (NYU Medical Center)
Title: ‘Nickel-induced cell transformation results in distinct epigenetic gene expression programs’
2:30 – 3:15 Mark Rothstein, J.D. (University of Louisville)
Title: ‘Legal and ethical implications of epigenetics’
3:15 Closing Comments – Dr. Ray York
10/27/10; Mark D. Noble, Ph.D., University of Rochester Stem Cell and Regenerative Medicine Institute, ““New insights into the regulation of CNS precursor cell function in development, response to environmental toxicants and in cancer”; 2:30-3:30 pm, CABM 010, Busch campus, Rutgers University
10/27/10; Bruce E. Johnson, M.D., Dana-Farber Cancer Institute, “Impact of Genomic Changes on the Treatment of Lung Cancer”, 4:00 pm-5:00 pm, CINJ Auditorium, New Brunswick, NJ
10/19/10; UMDNJ-Rutgers Center for Advanced Biotechnology and Medicine Symposium “Cancer, Progress and Prospects”
8:15 am Registration and Continental Breakfast
CABM South Atrium
9:00 am Welcoming Remarks
Aaron J. Shatkin, PhD
Professor and Director, CABM
Chairperson: Céline Gélinas, PhD
CABM Faculty Member and Professor of Biochemistry, Associate Dean for Research, UMDNJ-Robert Wood Johnson Medical School (RWJMS)
9:15 am David Baltimore, PhD
Robert Andrews Millikan Professor of Biology and President Emeritus, California Institute of Technology
“MicroRNAs: A Link between Inflammation and Cancer?”
10:00 am Pier Paolo Pandolfi, MD, PhD
George C. Reisman Professor of Medicine, Harvard Medical School, Associate Director of Research, Beth Israel Deaconess Cancer Center
“A Novel Biological Dimension for Coding and Non-coding mRNAs and its Role in Tumorigenesis”
10:45 am Coffee Break
Chairperson: Joseph Marcotrigiano, PhD
CABM Faculty Member and Assistant Professor of Chemistry and Chemical Biology, Rutgers University
11:15 am Joseph Schlessinger, PhD
William H. Prusoff Professor and Chair, Department of Pharmacology, Yale University School of Medicine
“Cell Signaling by Receptor Tyrosine Kinases: From Basic Principles to Cancer Therapy”
12:00 pm Carol Prives, PhD
DaCosta Professor of Biology and Chair, Department of Biological Sciences, Columbia University
“Target Gene Selectivity by Wild-Type and Mutant Form of p53”
12:45 pm Presentation of the Paul Janssen Award
1:00 pm Lunch Break
Chairperson: Kim Hirshfield, MD, PhD
Assistant Professor of Medicine, The Cancer Institute of New Jersey (CINJ), UMDNJ-RWJMS
2:00 pm Louis Staudt, MD, PhD
Deputy Chief, Metabolism Branch, National Cancer Institute, National Institutes of Health
“Converging on the Achilles Heel of Cancer using Functional and Structural Genomics”
2:45 pm William C. Hahn, MD, PhD
Associate Professor of Medicine, Dana-Farber Cancer Institute and the Broad Institute, Harvard Medical School
“Functional Genomics, Experimental Models and Cancer”
3:30 pm Coffee Break
Chairperson: Vassiliki Karantza, MD, PhD Assistant Professor of Medicine, CINJ, UMDNJ-RWJMS
4:00 pm Chi Van Dang, MD, PhD
Professor of Medicine, Oncology, Pathology, Cell Biology, Johns Hopkins Family Professor and Vice Dean for Research, Johns Hopkins University School of Medicine
“Therapeutic Opportunities at the Crossroads of Cancer Genes and Metabolism”
4:45 pm Thomas Lynch, MD
Richard Sackler and Jonathan Sackler Professor of Internal Medicine and Director, Yale Cancer Center
“Molecular Profiling of NSCLC 2010: Impact on Therapy”
10/22/10; Third Annual Skin Workshop, sponsored by the New Jersey Center for Biomaterials; Rutgers Life Science Building, Busch Campus, Piscataway, NJ. [link]
In acknowledgement of the European ban on testing personal care products on animals, a full day of scientific presentations and panels on alternatives and product development
Featuring Priya Batheja, Ph.D., of Capsugel/Pfizer, Nava Dayan, Ph.D., from Lipo Chemicals, Inc., and Richard Mendelsohn, Ph.D., of Rutgers-Newark.
Alternatives to Animal Testing
Cohost Dr. Bo Michniak-Kohn, Director, Laboratory for Drug Delivery & Industrial Membership Program, NJ Center for Biomaterials at Rutgers, and Jayne Mackta (Enrichment Record) address international perspectives on new products.
Taking Innovations to Market
Keynote speakers Dr. Neal Walker and Dr. Stuart Shanler of Vicept Therapeutics, on their experience in reformulating oxymetazoline hydrochloride (Afrin) to become a topical therapy for patients with Rosacea. A panel on tech transfer and intellectual property issues in personal care products will follow.
10/18/10, Dr. Kristen Verhey, University of Michigan, “Protein import into primary cilia”, 1:00 pm, Life Sciences Auditorium, Busch campus, Rutgers University
10/15/10, Hong-Gang Wang, Ph.D., Penn State, “ Bif-1/Endophilin B1: pinching off Atg9 vesicles from Golgi to form autophagosome?”, 12:00 pm, B228, Nelson Labs, Busch campus
10/13/10, "Linked Symposium on Models and Regulatory Issues in Drug Development", Ernest Mario School of Pharmacy, Rutgers University, Busch Campus, Piscataway, NJ
Rutgers Pharmaceutical Sciences Program Speaker:
12:00 pm- 1:00 pm: Bill Wei, Ph.D. Freeman Pharmaceutical; “Pharmaceutical product development through the 505(b)(2) regulatory path”,
EOHSI speaker sessions:
1:00 pm -2:00 pm: Michael A. Gallo, Ph.D., UMNDJ-Robert Wood Johnson Medical School, “Regulatory issues in developing ocular therapeutics”
2:00 pm – 3:00 pm: Jeffrey D. Laskin, Ph.D., UMNDJ-Robert Wood Johnson Medical School, “Drug development under the animal rule”
4:30 pm – 5:30 pm: Donald R. Gerecke, Ph.D., Rutgers University, “FDA rules for developing models for dermal antiinflammatory drugs”
10/8/10; Jianjie Ma, Ph.D., UMDNJ – Robert Wood Johnson Medical School, "Targeting MG53-mediated cell membrane repair in tissue repair and regeneration”, 12:00 pm, B228, Nelson Labs, Busch campus
10/8/10, Dr. Nilgun Tumer, Dept. of Plant Biology and Pathology, Rutgers University, “What makes ricin and Shiga toxin toxic?”, 3:30 pm, 207 Lipman Hall, Cook campus, Rutgers University.
10/6/10, Ariel Igal, M.D., Ph.D., Rutgers University, “StearoylCoA Desaturase-1: a key modulator of metabolic and signaling pathways in cancer”, ACFT Bldg, room 110, Cook campus, Rutgers University Sciences
10/6/10, Dr. David Mobley, University of New Orleans, “Predicting Protein-Ligand Binding Affinities from Molecular Simulations”, 1:30 pm, room 206, Hill Center, Busch campus, Rutgers University
9/29/10; Ryan Pelis, Ph.D., Novartis, “Drug transport: closing the gap in our understanding of drug disposition”, Room 202, Laboratory Cancer Research, Busch campus, 12:00 noon-1:00 pm.
9/29/10; John D. Hayes, University of Dundee, Scotland, “Regulation of redox signaling through the Keap1-Nrf2 pathway: implications for inflammation and cancer”; Room 202, Laboratory Cancer Research, Busch campus, 12:00 noon-1:00 pm.
9/29/10; The Fourth Annual New Jersey Stem Cell Symposium. Bridgewater NJ, Marriott Hotel
Keynote Speaker: Dr. Marius Wernig of Stanford University
We are honored to have Dr. Marius Wernig of the Institute of Stem Cell Biology and Regenerative Medicine and the Department of Pathology at Stanford University School of Medicine as the keynote speaker for the Fourth Annual New Jersey Stem Cell Symposium. Dr. Wernig is the leader in direct reprogramming of skin cells into neurons without passing through a pluripotent stem cell stage. Working with his postdoctoral mentor, Dr. Rudolf Jaenisch of MIT, Dr. Wernig built a mouse strain with drug-inducible, pluripotency transcription factors to demonstrate that every cell type can be converted to an iPS cell. He is a recipient of the Cozzarelli Prize in Biomedical Sciences for the article "Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease," which describes creating pluripotent cells from an animal and integrating these donor cells back into the animal brain to treat a disease. His interests include inducible pluripotency, tissue reprogramming, and epigenetic regulation during induction of pluripotency.
Panel Discussion: Advantages and Challenges of Corporate-Academic CollaborationsA prominent panel of academic and corporate scientists will discuss their experiences, goals, and recommendations for scientists wishing to establish collaborative projects between academia and industry across traditional boundaries.
Dr. Martin Grumet, Panel Chair, Professor, Department of Cell Biology & Neuroscience, Director, Rutgers Stem Cell Research Center, Rutgers University
Dr. Joachim Kohn, Board of Governors Professor of Chemistry and Chemical Biology, Director, New Jersey Center for Biomaterials, Rutgers University
Dr. Alan Harris, Vice President of Regenerative Medicine, Drug Development and Regulatory Affairs, Neostem, Inc.
Dr. Rodney Turner, Senior Director, Corporate Business Development, Life Technologies
Plenary Speaker: Gordana Vunjak-Novakovic, Ph.D, Professor, Department of Biomedical Engineering; and Director, Laboratory for Stem Cells and Tissue Engineering at Columbia University
Dr. Vunjak-Novakovic obtained a Ph.D. degree in chemical engineering at the University of Belgrade, in her homeland of Serbia. Upon moving to the USA, Dr. Vunjak-Novakovic spent twelve years at the Harvard-MIT Division for Health Sciences and Technology. As a Fulbright Fellow, she became fascinated by the concept of tissue engineering, and emerging technologies for improving and saving human life. She then joined Columbia University in 2005, where her laboratory hosts the Bioreactor Core of the NIH Center for Tissue Engineering. Dr. Vunjak-Novakovic's research is focused on engineering functional tissues for use as models of diseases, in regenerative medicine, and in studies of stem cells.
Special Guest Speaker: Ken Gaicin, Chairman & Chief Executive Officer of StemCyte, Inc.
Prior to joining StemCyte, Dr. Gaicin held positions as Senior Vice President of Independence Technology at Johnson & Johnson, Corporate Vice President at Church & Dwight/Arm & Hammer, and Vice President of Johnson & Johnson Baby Products Co.
9/28/10; Robert Casillas, Battelle Laboratories, “Assessing toxicity of sulfur mustard using mouse skin models”, Room 101, Carnegie Center, Princeton, NJ; 5:00 pm – 6:00 pm.
9/24/10; Alain Dabdoub, Ph.D., UCSD School of Medicine, "Sox2 is necessary for the development of neurosensory hair cells and auditory neurons in the mammalian cochlea", 12:00 pm, B228, Nelson Labs, Busch campus
9/24/10; Leaf Huang, Ph.D., Molecular Pharmaceutics, University of North Carolina, “Nanoparticle deliver of siRNA for cancer therapy”, 11:00 am-12:00 pm, Laboratory for Cancer Research, School of Pharmacy, Busch campus, Rutgers University.
9/22/10; Neil Mathias, Ph.D., Drug Deliver Alliance Team, Bristol-Myers Squibb, “Drug Delivery Technology Enablement and Challenges in Todays Pharmaceutical Industry”, 12:00 pm-1:00 pm, Laboratory for Cancer Research, School of Pharmacy, Busch campus, Rutgers University.
9/21/10; Dr. Scott Kennedy of HHMI-Memorial Sloan-Kettering Cancer Center, ”Mechanism and regulaton of meiotic recombination initiation”, CABM 010, Busch Campus, 12:00 Noon.
9/17/10; Patricia Fitzgerald-Bocarsly, Ph.D., UMDNJ – New Jersey School of Medicine, "Human plasmacytoid dendritic cells: rare cells with a big bite”, 12:00 pm, B228, Nelson Labs, Busch campus
9/16/10: Dr. Mark Brenneman, Rutgers University, Many Faces of Homologous Recombination", Life Sciences building, Busch campus, Piscataway, NJ, 11:00 am.
9/7/10, Jessica Tyler, University of Texas, ”Chromatin assemply and disassembly in transcription, repair and aging", Life Sciences Building, Busch Campus, Piscataway, NJ, 11:00 am.
6/16/10, Douglas R. Green, Ph.D., St. Jude Children's Research Hospital, “Mitochondria and Apoptosis: New Roads to Ruin”, 4:00-5:00 pm, UMDNJ-CINJ Auditorium, New Brunswick, NJ
5/21/10, Carl Decicco, Bristol-Myers Squibb, “Innovation in Drug Discovery”, 3:30 pm, Wright-Rieman Auditorium, Rutgers University, Piscataway, NJ
5/19/10, Amato J. Giaccia, Ph.D., Stanford University School of Medicine, “Targeting the HIF/VHL Pathway Therapeutically”, 4:00-5:00 pm, UMDNJ-CINJ Auditorium, New Brunswick, NJ
5/17/10, Dr. Paul Hasty University of Texas Health Science Center, San Antonio, Texas, “The impact of Ku70 and Ku80 on aging and cancer in mice”, 12:00-1:00 pm, Life Sciences Bldg. Auditorium, Rutgers University, Piscataway, NJ
Ku70 and Ku80 form a heterodimer called Ku that is essential for repairing DNA DSBs via the nonhomologous end joining (NHEJ) pathway. Defects in either Ku70 or Ku80 cause a severe hypersensitivity to ionizing radiation and genomic instability. Based on these observations, many predicted Ku were important tumor suppressors. However, we found mice mutated for either Ku70 or Ku80 exhibited low cancer levels along with premature aging and shortened life span. Low cancer levels could be due to either shortened life span that prohibited cancer development or due directly to Ku deletion. To address cancer levels, we showed that Ku80 mutation suppressed tumor formation and/or progression in APCMIN mice. We also showed that Ku80-mutant cells and tissues exhibited elevated levels of a p53/p21 DNA damage mediated response and elevated levels of DNA damage and chromosomal rearrangements. These data suggested that low cancer levels (and possibly early aging) are due to increased DNA damage responses to inefficiently repaired DNA damage. To prove this point we showed that mice mutated for both Ku and p53 exhibit elevated levels of pro-B cell lymphoma and medulloblastoma. Thus, deletion of either Ku70 or Ku80 caused early aging with low cancer levels. However, we also found that in a p53 mutant background, Ku70-deletion was not identical to Ku80-deletion suggesting that in some circumstances Ku70 and/or Ku80 might function outside the Ku heterodimer.
5/5/10; David Case, Rutgers University, "Critical Tests of the Quality of Protein Molecular Dynamics Simulations, in Solution and in Crystals", 12:00 CABM 010, Rutgers University, Piscataway, NJ
5/3/10; Dr. Keith Blackwell, Harvard University, Boston, MA, "Aging and stress defense in C. elegans", 12 pm, Life Sciences Aud., Rutgers University, Piscataway, NJ
4/30/10, Dr. Ann Weber, Merck Research Laboratories, “Adventures in Drug Discovery”, 11-12 pm, Wright-Rieman Auditorium, Rutgers University, Piscataway, NJ
4/21/10, Dr. Joel Rothman, University of California, Santa Barbara “Life and death, close relatives: roles for apoptotic regulators in non-apoptotic processes”, 2:00-3:00 pm, Waksman 1001, Rutgers University, Piscataway, NJ
The roles of critical apoptotic regulators in non-apoptotic processes, including chromosome separation, cell proliferation, and germline stem cell differentiation will be discussed. Our findings support the view that the regulatory machinery for programmed cell death was co-opted during evolution from components that functioned in growth and proliferation.
4/20/10, Tobin J. Marks, Harnessing center-surface and center-center cooperative effects for the catalytic synthesis of new polymeric materials, 11 am, Wright-Rieman Auditorium, Rutgers University, Piscataway, NJ
4/14/10, Hwyda Arafat, M.D., Ph.D., Thomas Jefferson University, Pennsylvania, “Nicotine in Pancreatic Cancer: Molecular Mechanisms” 4-5 pm, UMDNJ-CINJ Auditorium, New Brunswick, NJ
4/13/10, Dr. Vladimir Popik, University of Georgia, “Towards photoswitchable enediyne antitumor antibiotics: design, synthesis, photochemistry and cycloaromatization of prototype enediynes”, 11 am, Wright-Rieman Auditorium, Rutgers University, Piscataway, NJ
4/12/10; Dr. Jian-Jun Wei, Northwestern University, "Molecular genetics of ovarian cancer", 4 pm, CINJ Auditorium, New Brunswick, NJ
MicroRNAs (miRNAs) are a class of small, non-coding regulatory RNAs. MiRNAs regulate cell proliferation and differentiation by sequence-specific targeting of specific mRNAs and are aberrantly expressed in certain types of tumors. We are studying the roles of microRNA expression signatures in tumor progression, the predicted target genes, and multiple candidate pathways regulated by microRNA. Down regulation of several microRNAs is correlated with up regulation of HMGA2 in several gynecological tumors. Abnormal expressiono f HMGA2, an oncofetal protein, is associated with aggressive tumor growth, differentiation, metastasis, adverse outcome and resistance to treatment for many malignant tumors. We were able to establish a tumor model with HMGA2 overexpression which can be used for the early detection and potential therapeutic strategy in ovarian cancer.
4/7/10; Janet Davison Rowley, MD, University of Chicago, "Cancer: Genes Gone Wrong", 4 pm, CINJ Auditorium, New Brunswick, NJ
4/7/10; Tina Mayer, MD, Robert W Johnson Medical School, Cancer Institute of New Jersey, "Malignant Gliomas", 1:30, CAB 1302, New Brunswick, NJ
4/5/10, Dr. Edward Kipreos, University of Georgia, “The control of DNA replication and development by Cullin-RING ubiquitin ligases" 12:00-1:00 pm, Life Sciences Bldg. Auditorium, Rutgers University, Piscataway, NJ
4/2/10, Dr. Evgeny Rogaev, Rutgers University, “Ancient and historical DNA”, 9:30 am, room 138A, Foran Hall, Rutgers University, New Brunswick, NJ.
The evolution of extinct species and populations can be reconstructed by analysis of ancient DNA recovered from very old biological samples. Modern genomic methodologies provides also a novel tool in identification of historical specimens and genetic mutations that vanished into history. The examples will include evolutionary studies for pre-Holocene specimens and genetic identifications of historical remains for Imperial Nicholas II family and molecular cause of Queen Victoria Royal disease.
3/31/10; Candace S. Johnson, PhD, Roswell Park Cancer Institute, "Epigenetic Silencing of CYP24 in Tumor-derived Endothelial Cells", 4 pm, CINJ Auditorium, New Brunswick, NJ
3/31/10; M. Maral Mouradian, MD, UMDNJ/Robert Wood Johnson Medical School, "Targeting alpha-Synuclein as a Neuroprotective Therapeutic Strategy in Parkinson's Disease",1:30 pm, CAB 1302, New Brunswick, NJ
3/29/10; Dr. Ting Wu, Harvard Medical School, Boston, MA, "Homolog pairing, recombination, transvection, polycomb group genes", 12 pm, Life Sciences Aud., Rutgers University, Piscataway, NJ
3/24/10; Wah Chiu, Ph.D., Baylor College of Medicine, "Seeing Protein Sidechains and Cells with CryoEM", 12:00 pm, CABM 010, Busch Campus, Rutgers University, Piscataway, NJ
03/24/10, Dr. Sandy K. Pang, School of Pharmacy, University of Toronto, “Physiologically-based Pharmacokinetic (PBPK) Modeling in Transporter/Enzyme Interplay, 12:00 – 1:00 pm. School of Pharmacy, Rutgers University, Piscataway, NJ
03/23/10, Dr. Ravi Pillai, Life Sciences Division, Symrise, NJ, “Amphipathic Pentylene Glycol for Enhanced Delivery of Cosmetics and Pharmaceuticals”,12:30-1:30 pm, EOSHI Building, Rutgers University, Piscataway, NJ
3/8/10; Dr. Alla Grishok, Columbia University, "Contribution of short RNAs to regulation of gene expression through chromantin; epigentic phenomena in C. elegans", 12 pm, Life Sciences Aud., Rutgers University, Piscataway, NJ
3/3/10; Debra Laskin, Ph.D., Pharmacology and Toxicology, Rutgers University, "Pulmonary effects of inhaled sulfur mustard". 11 am, EOHSI 402, Busch campus, Rutgers University, Piscataway, NJ
2/12/10, Dr. Steven Castle, Brigham Young University, “New Strategies for the synthesis of unusual peptides and alkyloids, 3:30 pm, Wright-Rieman Auditorium, Rutgers University, Piscataway, NJ
2/10/10; Robert W. Doms, M.D., Ph.D. University of Pennsylvania, "HIV Entry and its Inhibition: New Antiviral and Gene Therapy Approaches", 12:00 CABM 010, Rutgers University, Piscataway, NJ
2/10/10; Steven Grant, M.D., Massey Cancer Center, "Cross-talk Between the ChK1 and MEK1/2/ERK1/2 Pathways", 4 pm, CINJ Auditorium, New Brunswick, NJ
2/10/10; "Dr. Elena Ezhkova, The Rockefeller University, New York, NY, "The Polycomb complex in mammalian skin development and stem cells", 12 pm, Life Sciences Aud., Rutgers University, Piscataway, NJ
Summary: Identification of molecular mechanisms that control the self-renewal and differentiation of stem cells is fundamentally important to understand both tissue development and the progression of various tissue disorders including cancer. Skin, the outermost barrier between body and environment, is an excellent model system to uncover these mechanisms as all its lineages, which include epidermis and hair follicles, originate from a single layer of embryonic skin stem cells. Moreover, the availability of genetic tools to perform in vivo loss- and gain-of function studies, the existence of well characterized molecular markers of stem cells and their differentiated progenies, as well as the possibility to purify and to culture skin stem cells makes skin a unique model system to uncover key regulators of stemness and differentiation. Increasing evidence has pointed to the importance of chromatin regulators in control of in vitro cultured embryonic stem cells, however their roles in control of stem cells in vivo are still largely unknown. Dr. Ezhkova's long-term interest is to elucidate the roles of chromatin regulators in stem cell regulation using skin as a model system. Her postdoctoral studies have revealed that a key chromatin regulator, the Polycomb repressor complex (PRC), represses the epidermal differentiation program and promotes the proliferation of embryonic skin stem cells. She identified that several essential Polycomb components are expressed in embryonic skin stem cells and are diminished concomitant with differentiation. Ezh2 controls proliferative potential of skin stem cells by repressing the Ink4A-Ink4B locus and tempers the developmental rate of differentiation by preventing premature recruitment of AP1 transcriptional activator to the genes that are required for epidermal differentiation. Together, Dr. Ezhkova's studies reveal that the Polycomb complex controls epigenetic modifications temporally and spatially in tissue-restricted stem cells. They maintain their proliferative potential and globally repressing undesirable differentiation programs while selectively establishing a specific terminal differentiation program in a stepwise fashion.
2/4/10; Marc Halfon University at Buffalo-State Univ. of New York, "Signals, Promoters & Enhancers: A toolkit for defining regulatory networks", 12 pm, Life Sciences Aud., Rutgers University, Piscataway, NJ
Summary: My laboratory is interested in understanding the regulatory circuitry that determines how cell fates are determined. We focus on the three central components of regulatory networks: intercellular signaling, transcriptional cis-regulatory modules (enhancers), and promoters. I will describe the approaches we have taken to develop a toolkit to allow for integrative studies of regulatory networks, and the biological insights we have garnered along the way.
2/03/10; Lawrence Chasin, Ph.D., Columbia Unversity, "Definition of Sequence Motifs Governing pre-mRNA Splicing", 4:00 pm, CINJ Auditorium, New Brunswick, NJ
2/2/10, Dr. Jonathan Sessler, University of Texas at Austin, “Oligopyrroles: receptors for potentially hazardous materials, 11 am, Wright-Rieman Auditorium, Rutgers University, Piscataway, NJ
2/1/10; Dr. Kristen Verhey, University of Michigan, "Molecular motors and microtubule based transport", 12 pm, Life Sciences Building, Busch Campus, Rutgers University, Piscataway, NJ
1/29/10; James A. Byrne, Ph.D., Stanford University School of Medicine, "Generation of isogenic pluripotent stem cells", 10:00 am, Nelson D-406, Rutgers University, Piscataway, NJ
1/27/10; Ravi Amaravadi, M.D., Abramson Cancer Center, "Mechanisms of Autophagy", 4 pm, CINJ Auditorium, New Brunswick, NJ
1/27/10; Mitsuhiko Ikura, University of Toronto, "Structural basis for regulation of intracellular calcium signals: A matter of life or death", 2:00 pm, CABM 010, Busch campus, Rutgers University, Piscataway, NJ
1/25/10; Dr. Bruce Goode, Brandeis University, "Overhauling actin machines using an integrated genetic and biochemical approach", 12 pm, Life Sciences Aud., Rutgers University, Piscataway, NJ
Summary: The goal of our research is to understand how actin networks are dynamically assembled and dismantled in vivo to transform cell shape and behavior. To dissect this process, we take a multidisciplinary approach that combines genetics, live-cell imaging, biochemistry, structure, and single molecule analysis. This seminar focuses on the mechanisms in cells that provide tight spatial and temporal control over key actin regulators such as Arp2/3 complex, formins, and ADF/cofilin.
1/20/10; Dr. Jin Billy Li, Harvard Medical School, "Targeted Sequencing of Genomic and Transcriptomic Variations", 11:30am-12:30 pm, Life Sciences Aud., Rutgers University, Piscataway, NJ
Summary: Next generation sequencing technologies hold the potential of revolutionizing genetic research. By developing genomic tools to capitalize on the sequencing power, we were able to identify genomic variations in exomes and methylomes, and transcriptomic variations derived from allele specific gene expression and RNA editing.
1/13/10; Dr. Danny Reinberg, New York University, "A Molecular Understanding of Epigenetics", 12:00 pm, CABM 010, Busch Campus, Rutgers University, Piscataway, NJ
1/11/10, Dr. David Sharp, Dept. Physiology and Biophysics, Albert Einstein College of Medicine, "Molecular mechanism of anaphase A", 12 pm, Life Sciences Aud., Rutgers University, Piscataway, NJ.
Summary: The movement and separation of chromosomes on the mitotic spindle is tightly linked to the active depolymerization of microtubule ends. This talk will focus on the roles of microtubule destabilizing and severing proteins in this process. We have found that chromatid to pole motion during anaphase A involves the coordinated action of multiple members of each protein class. The functional inter-relationships among these will be discussed.
12/15/09; Dr. Marion Gordon, Rutgers University, "Role of autophagy in ocular injury induced by sulfur mustard"; 4 pm. EOHSI Building, Busch Campus, Rutgers University, Piscataway, NJ
12/15/09; Dr. Cheryl Arrowsmith, University of Toronto, "Structural and chemical biology of methyllysine chromatin modifications"; 12:00 pm, Waksman Auditorium, Busch Campus, Rutgers Univ, Piscataway, NJ
12/13/09-12/15/09; The 102nd Statistical Mechanics Conference, "Thermodynamics, Statistical Mechanics, and Fundamental Issues in Biology: Where Do We Stand?", Hill Center, Rutgers Univ, Piscataway, NJ
12/11/09; Kenneth G. Paradiso, Ph.D., NIH/NINDS, "Can nerve terminals talk back? Small voltage changes at nerve terminals travel up axons to affect action potential initiation";10:00 am, Nelson D-406, Busch Campus, Rutgers University, Piscataway, NJ
12/08/09; Dr. Qingrong "Ron" Huang, "Improving Bioavailability of Phytochemicals/Drugs using Multiplatform Delivery Systems", Wright Rieman Auditorium, Busch Campus, Rutgers Univ, Piscataway, NJ
11/16/09;12 pm; Dr. Francisco M. De La Vega, Genetic Systems R and D, Life Technologies, Foster City, CA, "Understanding human genetic variation at the personal and population level through massively-parallel whole-genome sequencing"; Rutgers Life Sciences Building, Busch campus, Piscataway, NJ.
Ultra-high throughput sequencing is becoming a cost-effective method for the analysis of human genomes to discover genetic variation that could have implications in health and disease. We analyzed the SNPs and structural variants from the genomes of five diverse HapMap individuals. Our results suggest that much more genetic variation remains to be uncovered in human populations, in particular structural, which must be considered to obtain a complete picture of their functional impact in individual genome sequences.
11/4/09; 12:30-2:30; Wound Healing and Positive Deviance. Panelists: Diane Maydick, Director, Clinical Affairs, Derma Sciences and Curt Lindberg, Chief Learning & Science Officer, Plexus Institute. Conference Room C, EOHSI, Rutgers University, Piscataway, NJ.
Moving therapies and treatments from discovery to the patient implies a continuum of challenges that are met by different professionals. This panel will address opportunities and currently available products and strategies that impact wound healing.
Protein Folding, Evolution, and Dynamics, 11/3/09, CABM 010, Rutgers University, Piscataway, NJ. Moderator: Aaron Shatkin, Professor and Director, Center for Advanced Biotechnology and Medicine UMDNJ-Robert Wood Johnson Medical School
9:15 am, William F. DeGrado, Professor of Biochemistry and
Biophysics, University of Pennsylvania School of Medicine "Analysis and Design of Membrane Proteins"
10:00 am, Peter E. Wright, Professor and Chairman of Molecular Biology The Scripps Research Institute "Mapping Protein Folding Landscapes by NMR: New Insights into Pathways and Intermediates"
11:15 am, Dorothee Kern, HHMI Investigator, Professor of Biochemistry, Brandeis University, "The Choreography of a Protein's Dance"
12:00 pm, Anthony A. Kossiakoff, Professor of Biochemistry and Molecular Biophysics, The University of Chicago, "Synthetic Antibodies Generated Using a Minimalized Genetic Code: New Applications for Structural and Cell Biology"
2:00 pm, Frances Arnold, Professor of Chemical Engineering and Biochemistry, California Institute of Technology, "How Proteins Adapt: Lessons from Laboratory Evolution"
2:45 pm, Paul G. Falkowski, Professor II of Geological Sciences and Marine and Coastal Sciences, Rutgers University, "The Core Proteins that Drive Life on Earth"
4:00 pm, Eddy Arnold, Professor of Chemistry and Chemical Biology, Rutgers University and CABM Faculty Member, "Aiming at a Rapidly Evolving Target: Designing Inhibitors to Overcome HIV-1 RT Drug Resistance"
4:45 pm, David Eisenberg, HHMI Investigator, Director UCLADOE, Institute for Genomics and Proteomics, Departments of Biological Chemistry and Chemistry and Biochemistry, "A Structural Basis for Protein-encoded Inheritance"
11/2/09; 11:30-12:30; Dr. Alexander Schliep, Rutgers University, "Clustering Biological Data Using Mixture Models", DIMACS Center, CoRE Bldg, Room 431, Rutgers University, Busch Campus, Piscataway, NJ
9/30/09; 1:30 pm; Christopher T. Bever, Jr., MD, MBA, University of Maryland, School of Medicine; "Advances in Symptomatic Management of Multiple Sclerosis", Clinical Academic Building, 1302, New Brunswick, NJ
9/30/09; 1:30 pm; Robert Jernigan Iowa State University, 'Functional Protein Motions', Hill Center, Rm 260, Busch Campus, Piscataway, NJ
9/29/09; 3:00 pm, Jennifer H. Yearley, DVM, Ph.D., Drug Safety Evaluation, Bristol-Myers Squibb, New Brunswick, NJ, "Pathology and the Role of Pathologists in the Drug Development Process", EOHSI A/B, Rutgers Busch campus, Piscataway, NJ
9/29/09; 1:30 pm; Tack Kuntz, University of California, San Francisco (UCSF), "Physics based models of evolution" Hill Center, Room 260, Busch Campus, Piscataway, NJ
9/28/09, Dr. Tack Kuntz, University of California, San Francisco, "Physics-Based Models of Biological Evolution", 260 Hill Center, Busch Campus, Piscataway, NJ.
9/25/09; 9:15 am; Dr. Ann M. Stock, UMDNJ,RWJMS, Center for Advanced Biotechnology & Medicine, "Regulating Response Regulators", 138A Foran Hall, Cook Campus, Piscataway, NJ.
9/24/09; 12 noon; Lung Chi Chen, Ph.D., New York University, "All particles, great and small", EOHSI Conference Room C, Piscataway, NJ.
9/23/09; 1:30 pm; Ravi Sachidanandam, Mount Sinai School of Medicine, "Large Numbers of Small RNAs" Hill Center, Room 260, Busch Campus, Piscataway
9/23/09; 4 pm; Binghui Shen, Ph.D., City of Hope, Duarte, California, "Mutations in Human Flap Endonuclease-1 Results in Genome Instability and Inflammation-associated Cancer", CINJ Auditorium, New Brunswick
9/22/09; 1:30 pm; Howard Kipen, MD, MPH, Environmental & Occupational Health Sciences Institute, "Problems from Particles", EOHSI A&B, Busch campus, Piscataway
7/15/09 - Rutgers University Skin Symposium on Drug Discovery and Scale-up, Life Sciences Building, Busch Campus, Piscataway, NJ.
"Challenges in Skin Delivery" - Dr. Bozena Michniak-Kohn - Dr. Michniak-Kohn will present her current research on topical and transdermal drug transport and delivery, and the Lab's unique tissue-engineering approach to a human, full-thickness skin model for investigating barrier properties and testing cytoxicity in-vitro.
"Scale-up Scenarios" - What do you need to know to take your discovery from the bench to the bedside? Panelists will discuss process development, finance, and regulatory compliance- including the varied requirements for drugs, devices, and cosmetics.
Edith Lewis Rogers, MBA,
Executive Vice President of ESLR Associates, LLC
Dr. Neal Walker
Co-Founder, Octagon Research Services, Inc
Annette M. Tobia, Ph.D., J.D.
Founder and CEO, Dynamis Therapeutics, Inc
Michael J. McCreery, Ph.D.
Medical Countermeasures Against Radiological Threats
University of Maryland School of Medicine
"Weather Report on the Funding Climate"
Lifescience deal-making is not for the faint of heart. How can growing companies position themselves to attract support as they build pipeline for tomorrow's healthcare breakthroughs?
Angel funding, VC, government resources and licensing/acquisition will be discussed.
Walter Greenblatt, MBA,
Managing Director, Walter Greenblatt & Associates
6/26/09: Peter Nigro, M.D., M.P.H., Merck and Company, "Laboratory Animal Allergy: Setting an Exposure Limit", 1:30pm, 110 EOHSI, Busch Campus, Piscataway, NJ.
6/16/09; Debra Laskin, Ph.D., Rutgers University, "Macrophages, Inflammatory Mediators, and Tissue Injury", 11:30am-1:30pm, 110 EOHSI, Busch Campus, Piscataway, NJ.
6/15/09; Biomarker Research Technology Symposium, sponsored by the UMDNJ-Robert Wood Johnson Medical School DNA Core Facility, 9am-4pm, Auditorium A, Cancer Institute of New Jersey, New Brunswick, NJ.
6/15/09; Robert Hromas, Ph.D., University of New Mexico, "Metnase and its role in genome stability", 12:00 pm, Auditorium, Life Sciences Building, Busch Campus, Piscataway, NJ.
6/10/09 - Tocopherols in Inflammation and Cancer Prevention
‘Biochemical activities of tocopherols and epidemiology on tocopherols and cancer’
Dr. Robert Cooney, Cancer Research Center, University of Hawaii
‘Vitamin E forms: anti-inflammatory and anti-cancer activities’
Dr. Qing Jiang, Purdue University
‘Mechanisms of inhibition of prostate cancer by tocopherols’
Dr. Tony Kong, Rutgers University
‘Tocopherols and breast cancer prevention’
Dr. Nanjoo Suh, Rutgers University
‘Inhibition of colon and lung tumorigenesis by tocopherols’
Dr. Chung S. Yang, Rutgers University
6/8/09; Roscoe Brady, Ph.D., National Institute of Neurological Disorder and Stroke, NIH, "Current status and emerging strategies for the treatment of hereditary metablic storage disorders", 12:00 pm, Auditorium, Life Sciences Building, Busch Campus, Piscataway, NJ.
6/1/9; Bonnie Firestein, Ph.D., Rutgers University, "Regulation of Neuronal Development by NOS1AP", 12pm, Human Genetics Institute Auditorium, Busch Campus, Piscataway, NJ.
5/6/09; Miriam Meisler, Ph.D., University of Michigan, “Mutations in Endosomal-Lysosomal Trafficking and Neurodegenerative Disease in Human and Mouse”, 12:00 pm, CABM 010, Rutgers Busch campus
5/4/09; Joe Hacia, Ph.D., University of Southern California, "Human Genetics and Lipid Metabolism", 12:00 pm, Auditorium, Life Sciences Building, Busch Campus, Piscataway, NJ.
4/28/09; Perspectives in Medicinal Chemistry, Justin Lopchuk, Rutgers University, “Function-Oriented Synthesis: Overcoming the supply challenges for Bryostatin and Laulimalide” 12:00 noon, Rutgers School of Pharmacy, conference room 323A
4/28/09; Terry L. Orr-Weaver, Ph.D., Massachusetts Institute of Technology, “Developmental Regulation of DNA Replication”, 4 pm, Waksman Auditorium, Rutgers Busch campus, Piscataway
4/21/09; Perspectives in Medicinal Chemistry: Lin Chen, Rutgers University, “Antidrugs: A safer way for drug design” 12:00 noon, Rutgers School of Pharmacy, conference room 323A
4/20/09; Peter Stambrook, Ph.D., University of Cincinnati College of Medicine, "Cancer Cell Biology", 12:00 pm, Auditorium, Life Sciences Building, Busch Campus, Piscataway, NJ.
4/17/09; Gary Koretzky, Ph.D., Univ. of Pennsylvania School of Medicine, “Adaptor proteins in T cell signaling”, 12:00 pm, Nelson B228, Busch campus, Piscataway, NJ
4/14/09 - 4/16/09 - CounterACT 3rd Annual Meeting, Omni Shoreham Hotel, Washington, D.C.
4/1/09; Richard Rivlin, M.D., Weill Medical College of Cornell University, “Can Nutrition Prevent Cancer? New Approaches to Ancient Remedies” 4 pm, CINJ Auditorium, UMDNJ New Brunswick
3/31/09; Perspectives in Medicinal Chemistry: Herve Aloysius, Rutgers University, “Design and synthesis of targeted anticancer prodrugs activated by proteolysis”, 12:00 noon, Rutgers School of Pharmacy, conference room 323A
3/27/09; Ege Kavalali, Ph.D., Univ. of Texas Southwestern Medical Center, “Synaptic vesicle trafficking and its impact on neurotransmission”, 12:00 noon, Nelson B228, Rutgers, Busch campus.
3/25/09; George J. Weiner, M.D. The University of Iowa How to Make a Good Thing Better - Anti-cancer Monoclonal Antibody Mechanisms of Action Wednesday, March 25, 2009 16:00 CINJ Auditorium
3/24/09; Steve Marcus, MD, NJ Poison Information Control Center, “A Poison Potpourri”, 1:30 EOHSI A&B, Busch campus, Piscataway, NJ
3/24/09; Perspectives in Medicinal Chemistry: Yanping Xu, Rutgers University, “Lead Structures for the Discovery of Microtubule Stabilizers”, 12:00 noon, Rutgers School of Pharmacy, conference room 323A
3/23/09; Dmitri Zaykin, Ph.D., National Institute of Environmental Health Sciences, "Detecting Haplotype associations when important causative factors may not have been ascertained", 12:00 pm, Auditorium, Life Sciences Building, Busch Campus, Piscataway, NJ.
3/20/09; Ana Maria Cuervo, Ph.D., Albert Einstein College of Medicine, “Secective Autophagy; something more than a waste collector”, 12:00 pm, Nelson B228, Busch campus, Piscataway, NJ
3/04/09; 12 pm, Masayori Inouye, UMDNJ-Robert W Johnson Medical School, “Single Protein Production System for Direct Analysis of Structure”, CABM 010, Busch Campus, Piscataway, NJ
3/2/09; Clark Coffman, Iowa State University, Ames, IA, “Wanderings and fateful decisions: Using germ cells to elucidate the signaling networks regulating cell migration and programmed cell death”, 12:00 pm, Life Sciences Bldg. Auditorium, Busch campus, Piscataway, NJ
2/27/09; Howard A. Young, Ph.D., National Cancer Institute, “Regulation of Interferon-gamma gene expression” 12:00 pm, Nelson B228, Busch campus, Piscataway, NJ
2/25/09; Chris Takimoto, M.D., Ph.D. Ortho Biotech Oncology R&D The Modern Oncology Phase 1 Trial: Teaching an Old Dog New Tricks Wednesday, February 25, 2009 16:00 CINJ Auditorium
2/24/09; Marion Gordon, Ph.D., Rutgers University, "Epithelial Healing after Sulfur Mustard Exposure"; 1:00-2:00 pm, sponsored by The New Jersey Skin Club, JSJ Pharmaceuticals, Inc, and Target Health Inc., conference room C, EOHSI, Busch campus, Rutgers, Piscataway, NJ
2/24/09; Christina Tan, MD, NJ Dept of Health and Senior Services Communicable Disease Service, "Pandemic Influenza Issues" , 1:30 pm, EOHSI A&B, Busch campus, Piscataway, NJ
2/24/09; Stephen Moorman, Ph.D., Hatem Sabaawy, M.D., Monica Driscoll, Ph.D., and Ruth Steward, Ph.D.; Animal Models to Understand Biology and Human Disease Tuesday, February 24, 2009 15:30 CABM 010
2/18/09; Theodore L. DeWeese, M.D. Johns Hopkins University Altering Cellular Radiation Response: Do We Need Targeted Agents?" Wednesday, February 18, 2009 16:00 CINJ Auditorium
2/18/09; Andrej Skerjanec, Ph.D., Novartis, "Role of Pharmacokinetics in Drug Development", 12:00-1:20 pm; room 111, Pharmacy Building, Busch campus, Rutgers, Piscataway, NJ
2/17/09; Jun-Yan Hong, PhD, UMDNJ-School of Public Health, "Impact of Genetic Factors on an Individual's Susceptibility to Environmental Disease"; 1:30 pm, EOHSI A&B, Busch campus, Piscataway, NJ
2009 Minicourse: Current Concepts of Immunology
Location: Room V-10 of the RWJMS Research Tower, Busch Campus, Piscataway NJ
This course provides current concepts of immunology. It will emphasize the organization and evolution of the immune system, the genetic basis of antibody diversity, MHC gene structure and function, development and selection of lymphocytes, lymphocyte activation, and the regulation of immune tolerance. It will also review the effector mechanisms of immune reactions, antigen-antibody reactions, cytokines, and cell-mediated immune responses.
1/17/09; ‘Introduction and History of Immunology’, Yufang Shi, Robert Wood Johnson Medical School
1/22/09; ‘Innate Immunity/Toll-like receptors’, Beverly Barton, NJ Medical School
1/24/09; ‘Hematopoiesis’, Arnold Rubin, Robert Wood Johnson Medical School
1/29/09; ‘Cells and Tissue of the Immune System’, Debra Laskin, Rutgers University & CounterACT Research Center of Excellence
1/31/09; ‘Antibody structure and antibody diversity – B-cell and T-cell receptor’, Beverly Barton, NJ Medical School
2/5/09; ‘MHC Molecules’, Alexander Izaguirre, Robert Wood Johnson Medical School
2/7/09; ‘Antigen presentation/Dendritic Cells’, Alexander Izaguirre, Robert Wood Johnson Medical School
2/12/09; ‘T-cell Development’, Guy Werlin, Rutgers University
2/14/09; ‘Lymphocyte Signal Transduction’, Arnold Rabson, Cancer Institute of New Jersey
2/19/09; ‘B-cell Development’, Lorie Covey, Rutgers University
2/21/09; ‘Complement’, Wenchao Song, University of Pennsylvania
2/26/09; ‘Interferons and Immune Response’, Sidney Pestka, Robert Wood Johnson Medical School
2/28/09; ‘Cytokine and Immune Responses’, Beverly Barton, NJ Medical School
3/5/09; ‘Type 1 and Type 2 helper cells’, Gobardhan Das, Aventis
3/7/09; ‘NK, NKT and Innate-Like T cells’, Gobardhan Das, Aventis
3/14/09; ‘Tumor Immunology’, Edmund Lattime, Cancer Institute of New Jersey
3/19/09; ‘Immune Regulation and Tolerance’, Yufang Shi, Robert Wood Johnson Medical School
3/21/09; ‘Vaccine Development’, Edmund Lattime, Cancer Institute of New Jersey
3/26/09; ‘Immunity in Infectious Diseases’, Yufang Shi, Robert Wood Johnson Medical School
3/28/09; ‘Phylogeny of the Immune System’, Yufang Shi, Robert Wood Johnson Medical School
4/2/09; ‘Mechanisms of Apoptosis and Cytotoxicity’, Yufang Shi, Robert Wood Johnson Medical School
4/9/09; ‘Immunosuppression and Transplantation’, Yufang Shi, Robert Wood Johnson Medical School
4/11/09; ‘Autoimmunity’, Leonard Sigal, Bristol-Myers Squibb
4/16/09; ‘Psychoneuroimmunology’, Alexander Kusnecov, Rutgers University
4/18/09; ‘Immunodeficiency’, Leonard Sigal, Bristol-Myers Squibb
4/23/09; ‘Allergy and Hypersensitivity’, Paulo Cesar Maciag, Advaxis, Inc.
4/25/09; ‘Transformation and Malignancy of the Immune System’, Roger Strair, Robert Wood Johnson Medical School
4/30/09; ‘Immunology Techniques’, Paulo Cesar Maciag, Advaxis, Inc.
2/11/09; Larry Norton, M.D., Memorial Sloan Kettering Cancer Center, “New Concepts Regarding the Nature of Malignancy”, 4:00 pm, CINJ Auditorium, Piscataway, NJ
2/4/09; Martin Yarmush, Rutgers University, “Metabolic Engineering - Analysis in Traumatic Injury”, 12:00 pm, CABM 010, Busch campus, Piscataway, NJ
2/2/09 - Dr. Robert Hromas, Indiana School of Medicine, "Metnase and its role in genone stability", 12 pm, Human Genetics Institute-Auditorium, Busch campus, Piscataway, NJ
2/2/09; Leonard Lipovich, Wayne State School of Medicine, Detroit, MI, “Glimpsing the mammalian transcriptome's "other half:" Evolution, expression, and function of long non-protein-coding RNA”, 12:00 noon, Life Sciences Bldg. Auditorium, Busch campus, Piscataway, NJ
1/27/09; Marie Classon, Harvard Medical School, Boston, MA, “A protein identity crisis in the RB tumor suppressor pathway and a tale of resistance”, 12:00 noon, CABM 010, Busch campus, Piscataway, NJ
1/26/09; Francisco M. De La Vega, Genetic Systems R&D LIfe Technologies, Foster City, CA, “SOLiD Sequencing”; 12:00 noon, Life Sciences Bldg. Auditorium, Busch campus, Piscataway, NJ
1/21/09; R. Ariel Igal, M.D., Ph.D., Rutgers University, “Role of Stearoyl-CoA desaturase-1, a key lipogenic enzyme, in regulating cell proliferation and survival”; 4:00 pm, CINJ Auditorium, New Brunswick, NJ
1/20/09; Perspectives in Medicinal Chemistry: Joyce Shuman, Rutgers University, “Bioisosteric replacement in the synthesis of potent and selective CB1 and CB2 receptor targets”, 12:00 noon, Rutgers School of Pharmacy, conference room 323A
1/14/09, George Vande Woude, Ph.D., Van Andel Research Institute, Grand Rapids, Michigan, "Met and Malignant Progression" 4 pm, CINJ Auditorium, Piscataway, NJ
-12/15/08 - Dr. Robert Klein, Memorial Sloan Kettering Cancer Center, "Genome-wide association studies related to cancer", 12 pm, Human Genetics Institute-Auditorium, Busch campus, Piscataway, NJ
12/11/08; Neal Zondlo, Ph.D., University of Delaware, “Design of Tunable Proteins via Phosphorylation, Electronics and Stereoelectronic Effects”, 4 pm, UMDNJ Tower, V10, Busch campus, Piscataway, NJ
12/11/08; 12 pm, Paul Kantor and William Pottenger, “Current Challenges in Search and Data Mining: The War on Terror”, DIMACS, Rutgers University, DyDAn Center, CoRE Bldg, Room 431, Rutgers University, Busch Campus, Piscataway, NJ
12/9/08; 12:00 noon, Daigo Inoyama, Ernest Mario School of Pharmacy, "Antibody Directed Prodrug Therapy"; Levine Hall, Rutgers Busch campus, Piscataway, NJ
12/08/08 - Dr. Carola Neumann, University of South Carolina, "Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity", 12 pm, Human Genetics Institute-Auditorium, Busch campus, Piscataway, NJ
12/08/2008, 12:00 pm; Gaetano Montelione, Rutgers University, “The NIH Protein Structure Initiative: Achievements and Visions for the Future”, CABM 010, Piscataway, NJ
11/30/08, Eric Weren, MS, New Jersey Department of Health and Senior Services, "Hazard communication and right-to-know", 1:30 pm, EOHSI A&B, Busch campus, Piscataway, NJ
11/25/08; Michael Gallo, PhD, Environmental and Occupational Health Sciences Institute, "Environmental Carcinogenesis", 1:30pm, EOHSI A&B, Busch campus, Piscataway, NJ
11/18/2008, 1:30 pm, Eric Weren, New Jersey Department of Health and Senior Services, “Hazard communication and right-to-know”, EOHSI rooms A&B, Busch Campus, Piscataway, NJ
11/17/2008, 12:00 pm; Peter E. Warburton, Mount Sinai School of Medicine, NY, “The epigenetics of human centromere formation” Life Sciences Bldg. Auditorium, Busch Campus, Piscataway, NJ
11/14/2008; 12:00 pm; Erika Bach, New York University Medical School, “Roles of the JAK/STAT pathway in growth and stem cell self-renewal”, Waksman Bldg 1001, Busch Campus, Piscataway, NJ
11/12/2008; 12:00 pm, Vishwas Rai, Dept. Pharmaceutics, Rutgers School of Pharmacy, “Use of human skin equivalents for percutaneous absorption”, Pharmacy Building, 007, Busch Campus, Piscataway, NJ
11/05/08, Dr. Simon N. Powell, Memorial Sloan Kettering Cancer Center, "The Importance of Homologous Recombinational Repair in Human Tumors: The Role of the BRCA1 and BRCA2 Tumor Suppressors", 4 pm CINJ Auditorium, New Brunswick, NJ
10/29-10/31: 9th New Jersey Symposium on Biomaterials Science and Regenerative Medicine. Hyatt Regency Hotel, New Brunswick, NJ.
Blast, Burn and Crush Injuries
Biomaterials Design and Fabrication
Cell-Material Interactions Relevant to Tissue Engineering
Clinical Approaches to the Reconstruction of Bone, Tendon, Cartilage
Predictive Modeling of Cell-Material Interactions
Nerve, Muscle, Soft Tissue Regeneration and Vascularization
Skin Regeneration and Wound Healing
Protein Adsorption and Cell-Material Interactions
Allograft Cell and Tissue Transplantation
10/28 - Sgt. Clyde Banks Jersey City Police Special Operations Training/ Emergency Service, “First Responder Self Protection”.
10/22 - David Botstein, Princeton University, How the Genome and the Computer are Changing Biomedical Science, 4pm, CINJ Auditorium
10/21 - Sixth Annual New Jersey Office of Homeland Security Counter-Terrorism Conference, 8:30am, Trenton War Memorial, Trenton, NJ. For more information, click here.
10/21 - Dr Richard Ebright, Howard Hughes fellow and Professor of Chemistry, Waksman Institute, Rutgers U., Piscataway, NJ “Biodefense Research, NIH Role, NIH Management and Oversight of Safety and Security of Infectious Agents.
10/16/08; Rutgers University/UMDNJ Center for Advanced Biotechnology and Medicine Symposium, Waxman Institute Auditorium, Busch Campus, Rutgers University
David Eisenberg, UCLA, "Protein-protein interactions identified by X-ray cystallography and computational biology"
Stanley Fields, University of Washington, "Development of analytical methods to identify protein function"
Clair Fraser-Liggett, University of Maryland, "Microbial communities in health and disease"
Gaetano Montelione, Rutgers University, "NMR spectroscopy as a tool for protein engineering and structural bioinformatics"
Peter Lansbury, Harvard University, "Protein pathogenesis"
Chris Sander, Sloan-Kettering, "Frontiers in computational biology"
Jonathan Weissman, USCF, "Protein folding in the endoplasmic reticulum"
10/9/08; Jin Montclare, Ph.D., SUNY Downstate Medical Center, “Artificial Proteins: Combining Genetic and Chemical Diversity”, 4 pm, UMDNJ Tower, V10, Busch campus, Piscataway, NJ
10/8/08; Neil Bhowmick, Vanderbilt University Medical Center, "Novel Approaches to Drug Discovery and Diagnostics", 4 pm, CINJ main auditorium, New Brunswick, NJ
10/7/08 Dr. Nancy Connell, UMDNJ-Newark, "Biological and Toxin Weapons: research at UMDNJ's Center for BioDefense, 3:30pm, Conference Room C, EOHSI, Busch Campus, Rutgers University
9/30/2008 Second Annual Skin Workshop “New Developments in Dermaceuticals and Wound Care”, 10 am - 4 pm; Center for Biomaterials, Busch campus, Piscataway, NJ
Hosts: Dr. Bozena Michniak-Kohn, Director of the Laboratory for Drug Delivery, The New Jersey Center for Biomaterials and The New Jersey Chapter of the Controlled Release Society
Bruce Redding, PhD, Encapsulation Systems,"Ultrasonic Delivery Through the Skin"
Sameer Shums, Biocure,"Gelspray Liquid Bandage Development"
Jeff Berg, Hill Top Research, NJ,"Wound Healing - Evaluations in a Clinical Environment"
Mark Garrison, Avon, NY,"The Art and Science of Skin Care Formulation"
Jules Mitchel, PhD,Target Health, NY,"Developing Clinical Data Using the Internet"
Marjana Tomic-Canic, PhD, NY Hospital for Special Surgery, NY,"Biology of Wound Healing and its Pathogenesis"
9/25/08; Scott Banta, Ph.D., Department of Chemical Engineering, Columbia University; “Self-assembling enzymatic hydrogels from designed bifunctional building blocks”, 4 pm, UMDNJ Tower, V10, Busch campus, Piscataway, NJ
9/15/08, Tara Matise, Ph.D., Rutgers University, "Analysis of human chromosome 14", Genetics building, Busch campus, Rutgers University.
9/11/08; Terry Gordon, Ph.D., New York University, “The role of age and gender in the genetic susceptibility to inhaled toxicants- animal models”, EOHSI Conference room C, Busch Campus, Piscataway, NJ
9/9/8 - Ronald M. Evans, PhD, "Nuclear Receptors and Energy Metabolism", Howard Hughes Medical Institute; The Salk Institute for Biological Studies, La Jolla, California. 4pm, UMDNJ-RWJMS Auditorium, Piscataway, NJ
8/21/08 - 8/22/08; Workshop on Computational Issues in Genetic Epidemiology; DIMACS Center, CoRE building, Rutgers University, Piscataway, NJ
Thursday, August 21, 2008
8:20 - 8:30 Welcome and Opening Remarks
Fred Roberts, DIMACS Director
8:30 - 9:15 Incorporating "Known" Biology into
Analysis and Interpretationof Genome-wide Association Studies
Peter Kraft, Harvard University
9:15 - 10:00 Use of Empirical Kinship Matrices in Whole Genome Case-Control Studies
of Disease in Stratified Populations
Daniel Stram, University of Southern California
10:00 - 10:30 Break
10:30 - 11:00 Things to know when using Affymetrix 6.0
Mariza de Andrade, Mayo Clinic
11:00 - 11:30 A Constrained Regression Approach for Studying
Jung-Ying Tzeng, North Carolina State University
11:30 - 12:00 Fast and Robust Association Tests for Untyped SNPs in
Michael Epstein, Emory University
12:00 - 1:30 Lunch
1:30 - 2:00 Computational Investigation of Gene Regulation
Sridhar Hannenhalli, University of Pennsylvania
2:00 - 2:30 Mathematical Structure and Optimization Approaches to
Daniel Brown, University of Waterloo
2:30 - 3:00 Inference of Complex Genealogical Histories In Populations
and Its Application in Mapping Complex Traits
Yufeng Wu, University of Connecticut
3:00 - 3:30 Break
3:30 - 4:00 Multi-SNP Association Mapping using Bayesain Regression and
Yongtao Guan, University of Chicago
4:00 - 4:30 On a Method to Estimate the Number of Unseen Variants in the
Iuliana Ionita, Harvard University
4:30 - 5:00 Linkage Disequilibrium Based Single Individual Genotyping
from Low-Coverage Short Sequencing Reads
Justin Kennedy, University of Connecticut
5:30 Dinner at DIMACS
Friday, August 22, 2008
8:30 - 9:15 New Haplotype Sharing Method for Genome-Wide Case-Control
Association Studies Implicates Gene for Parkinson's Disease
Glen Satten, Centers for Disease Control and Prevention
9:15 - 10:00 Calibrating the Performance of SNP Arrays for Whole-Genome Association Studies
John Storey, Princeton University
10:00 - 10:30 Break
10:30 - 11:00 The Genetics of Quantitative Traits: what has Changed since
Chiara Sabatti, UCLA
11:00 - 11:30 Increasing Power in Association Studies by using Linkage Disequilibrium
Structure and Molecular Function as Prior Information
Eleazar Eskin, UCLA
11:30 - 12:00 Genome-Phenome Association: Computational Challenges and new Algorithms
Eric Xing, Carnegie Mellon University
12:00 - 1:30 Lunch
1:30 - 2:00 Estimating Local Ancestry in Admixed Populations
Eran Halperin, International Computer Science Institute
2:00 - 2:30 Whole Population, Genomewide Mapping of Hidden Relatedness
Itsik Pe'er, Columbia University
2:30 - 3:00 Inferring Ancestry Efficiently in Admixed Populations
Sivan Bercovici, Technion
3:00 - 3:30 Reconstructing Sibling Relationships from Microsatellite Data
Tanya Berger-Wolf, University of Illinois at Chicago
There is strong evidence that genes play a major role in susceptibility to all common human diseases. While linkage analysis has been very successful in finding the genes involved in Mendelian diseases such as Huntington disease, early onset Alzheimer's disease and cystic fibrosis, current interest has shifted towards mapping genes involved in diseases with complex etiologies such as diabetes and cancer, for which association studies have been shown to be more powerful. The workshop will bring together computer scientists, geneticists, and statisticians aiming to address current computational challenges in gene mapping, which include dealing with complex missing data patterns, multiple hypotheses testing, population substructure, gene-gene and gene-environment interactions. New directions of research, such as capturing the effects of structural genomic variation and using biological networks in whole-genome studies, will also be investigated.
8/11/08 - Dr. Tuula Kallunki, Apoptosis Department, Institute of Cancer Biology, Danish Cancer Society, Denmark. "Functional Identification of Signaling Pathways Regulating ErbB2 Mediated Cell Growth", 12pm, RWJMS, Room V-10.
8/4/08: Dr. Ning Sun, Biostatistics Division, Yale School of Public Health, Yale University School of Medicine, New Haven, CT: "Regression models for dissecting transcriptional regulatory network", 12 pm, Life Sciences Bldg Auditorium, 145 Bevier Rd., Busch Campus.
7/17/2008; 12 pm, Wenlai Zhou, University of California, Histone ubiquitination in inflammation and cancer, CABM 010, Busch campus, Piscataway, NJ
7/14/2008; 4 pm, Amale Laouar, Harvard Medical School, Innate immunity of a novel mucosal-specific antigen presenting cell type; CABM 010, Busch campus, Piscataway, NJ
6/28/08; Dr. Jianlong Wang, Children's Hospital, Boston, MA, “Biochemical Basis and Regulatory Circuitry for Pluripotency of Embryonic Stem Cells” 4:00 pm, CABM 010, Busch campus, Rutgers University
6/25/08 - Drs. Gary Grover and Richard Kronenthal, Eurofins-Product Safety Labs//Orthocon, Inc. “Trends in the Pharmaceutical Industry//Medical Device Commercialization--Past, Present, and Future”; 12:00 pm, CABM 010, Busch campus, Rutgers University
6/10/08; 10am-3pm, UMDNJ/Rutgers CounterACT Sulfur Mustard Symposium; EOHSI Conference Room C, Rutgers Busch Campus, Piscataway, NJ
10:00 - 10:45am; Jeffrey D. Laskin, Ph.D., UMDNJ-Robert Wood Johnson Medical School, “Overview of Ongoing Research at the UMDNJ-Rutgers Sulfur Mustard CounterACT Research Center”
10:45-11:30 am; Debra L. Laskin, Ph.D., School of Pharmacy, Rutgers University, ”Mechanisms of Sulfur Mustard Lung Toxicity”
11:30- 1:00 pm; Lunch and round table discussion; moderator, Otto Mills, Department of Medicine, UMDNJ-Robert Wood Johnson Medical School
1:00- 1:30 pm; Donald Gerecke, Ph.D., School of Pharmacy, Rutgers University, “ Countermeasures for sulfur mustard poisoning: A cocktail anyone? A seminar sponsored by the New Jersey Skin Club.
1:30- 2:30 pm; Alireza Hosseini- Khalili, MD, University of Connecticut, Storrs, CT/ Janbazan Medical and Engineering Research Center, Tehran, Iran, “Sulfur Mustard Lung- Latest Findings on Long-Term Respiratory Effects of Mustard Gas: Experiences of the Iranians” A seminar sponsored by Clinical Research and Occupational Medicine Grand Rounds in EOHSI.
2:30- 3:30 pm; Breakout session, moderator, Paul Lioy, Ph.D., Department of Environmental and Occupational Medicine, UMDNJ-Robert Wood Johnson Medical School, “Exposure Assessment following Sulfur Mustard Exposures; Concepts in Dose Exposure Modeling”
6/10/08; Alireza Hosseini- Khalili, M.D., University of Connecticut, Storrs, CT/ Janbazan Medical and Engineering Reseach Center, Tehran, Iran, “Mustard Lung- Latest Findings on Long-Term Respiratory Effects of Mustard Gas: Experiences of Iranians; 1:30 pm, conference room A/B, Busch Campus, Piscataway, NJ
Mustard gas was a widely used chemical warfare agent during World War I and more recently in the Iran-Iraq. As a highly toxic alkylating agent, MG causes severe dermal, respiratory and ocular injuries. Iran is the only country in the world with a large population of patients still suffering from exposure to chemical warfare agents. According to official medical records, more than 50,000 of Iranians are suffering from late complications of mustard gas exposure, mainly in respiratory system. This presentation will review briefly late respiratory complications of mustard gas and discuss clinical and para-clinical findings including: pathology, radiology, PFT, bronchoscopy, and treatment strategies.
6/9/8 - BioMaPS Institute for Quantitative Biology - Mathematical Biology Symposium- Rutgers Biological Physics
June 9: Chromatin structure and genomic studies of chromatin
Session Chair: Vincent Pirrotta, Rutgers University
9:20 - 9:30 AM: Alexandre Morozov & Vasily Studitsky - Introduction and welcoming remarks
9:30 - 10:30 AM: Kevin Struhl (KEYNOTE SPEAKER, Harvard Medical School) “Transcriptional regulatory mechanisms and epigenetic inheritance”
10:30 - 12:00 Noon: Jeff Hayes* (University of Rochester Medical Center) "Intra- and inter-nucleosome interactions of the core histone tail domains"
12:00 - 1:30 PM: Lunch Break
1:30 - 2:30 PM: Vincent Pirrotta (Rutgers University) "Polycomb mechanisms and genomic programming"
2:30 - 3:30 PM: Frank Pugh (Penn State University) "Organization of chromatin and the transcription machinery throughout the yeast and fly genomes"
3:30 -3:45 PM: Break
3:45 - 4:45 PM Jason Lieb (University of North Carolina, Chapel Hill) "Chromatin-mediated mechanisms for the regulation of genome accessibility in yeast, worms, and humans"
June 10: Computational modeling of chromatin states
9:30 - 10:00 AM: Swagatam Mukhopadhyay* (Rutgers University) "Introduction to the polymer physics of chromatin"
10:00 - 11:00 AM:Anirvan Sengupta (Rutgers University) "Epigenetic chromatin silencing"
11:00 - 12:00 Noon:Wilma Olson & Guohui Zheng (Rutgers University) "Flexing and Folding of nucleosome-bound DNA"
12:00 - 1:30 PM: Lunch Break
1:30 - 2:30 PM: Alexandre Morozov (Rutgers University) "Biophysical models of chromatin structure and gene regulation"
2:30 - 3:30 PM: Victor Zhurkin (NIH) "A new model for the linker histone binding based on comparative sequence analysis of chicken and yeast nucleosomal DNA"
3:30 - 3:45 PM: Break
3:45 - 4:45 PM: Guocheng Yuan (Harvard School of Public Health)"Prediction of nucleosome positions"
June 11: Histone modifications and signaling
9:30 - 11:00 AM: Sergei Grigoryev (Penn State University College of Medicine) “Inter-nucleosome interactions in chromatin higher-order packing”
11:00- 12:00 Noon: Patrick Grant (University of Virginia) "The SAGA of Histone Modifications"
12:00 - 1:30 PM: Lunch Break
1:30 - 2:30 PM: Sepideh Khorasanizadeh (University of Virginia) “Diversity in Chromatin Docking Interactions of Chromodomains”
2:30 - 3:30 PM: Ruth Steward (Rutgers University) "Functional importance of Histone H4K20 methylation"
3:30 -5:30 PM: Poster Session
June 12: Chromatin remodeling and transitions
9:30 - 11:00 AM: David Clark* (NIH) "Gene Activation in Yeast: Chromatin Remodeling and Nucleosome Dynamics"
11:00 - 12:00 Noon: Vasily Studitsky (UMDNJ) “Mechanism of nucleosome survival and chromatin remodeling during transcription by Pol II”
12:00 - 1:30 PM: Lunch Break
1:30 - 2:30 PM: Blaine Bartholomew (Southern Illinois University School of Medicine) “Mechanism of ATP-dependent chromatin remodeling: lessons from ISW2 and SWI/SNF”
2:30 - 3:30 PM: Paul Kaufman (University of Massachusetts Medical School) “Histone Modification, Deposition, and Turnover”
3:30 - 3:45 PM: Break
3:45 - 4:45 PM: Thomas Kusch (Rutgers University) “Mix and Match: Landscaping Chromatin during Transcription”
June 13: Programming functional chromatin states
9:30 - 10:30 AM: Gary Felsenfeld (NIH) “The establishment and maintenance of chromatin boundaries”
10:30 - 10:45 AM: Break
10:45 - 11:45 AM: Marc Gartenberg (UMDNJ) "The Rise and Fall of Models for Heterochromatin Establishment"
11:45 - 12:45 PM: Dmitry Fyodorov (Albert Einstein College of Medicine) “ATP-dependent chromatin assembly”
12:45 - 1:00 PM: Alexandre Morozov & Vasily Studitsky: Closing Remarks
6/1/08 - 6/6/08 - Bioscience Review 2008. Baltimore Marriott Hunt Valley Inn, Hunt Valley, Maryland.
Bioscavengers and Biotechnology
Cutaneous and Ocular Therapeutics/Vesicant Countermeasures
Clinical Perspectives of Chemical Exposures
Partnerships, Collaborations, and Consultations
5/30/08; Peter R. Holt, M.D., Rockefeller University; “Chemistry applied to human disease”; 10:30 am, room 200, Rutgers School of Pharmacy, Busch campus, Piscataway, NJ
5/28/08; 3:00 pm, Dr. Stephen Friend, Executive Vice President, Oncology, Merck Research Laboratories, Merck & Co., Inc, “Innovations in New Drug Development Through Translational Research; Main auditorium; UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ
5/28/08; 11:00 am, Dr. David Allis, Laboratory of Chromatin Biology, The Rockefeller University; “Beyond the Double Helix: Writing and Reading the "Histone Code"; Main auditorium; UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ
5/16/08-5/21/08 - American Thoracic Society International Meeting - Toronto, Canada Look for our research to be presented at this annual meeting.
5/15/08; Paul Talalay, M.D. The Johns Hopkins University School of Medicine, “Chemoprevention of disease: a strategy whose time has come”; 4:00 pm, room C; Environmental & Occupational Health Sciences Institute, Busch Campus, Piscataway, NJ
5/14/08 - James Manley Columbia University Mechanisms of post-transcriptional gene control Wednesday, May 14, 2008 12:00 CABM 010
5/7/08; 1:00 pm. Frank J. Gonzalez, Ph.D., National Cancer Institute, “Mechanism of Action of Non-Genotoxic Carcinogens”, Elizabeth C. Miller and James A. Miller Distinguished Lecture Series on Cancer, Rutgers Pharmacy Building, room 111, Busch campus, Piscataway, NJ
5/06/08, 12:00 pm; Dr. Hays Rye, Princeton University,”Molecular chaperones in protein folding and endocytosis”, CABM 010, Busch campus, Rutgers University, Piscataway, NJ
5/01/08; 1:00 pm; Elizabeth Schonauer, DNA Genotek, ‘Overview of DNA and RNA collection methods, CINJ Auditorium, New Brunswick, NJ
4/30-5/1 - ebCTC Annual Symposium on Systems Toxicology. EOHSI, Rutgers, Piscataway, NJ.
Wednesday, April 30
09:30 - 10:30 AM
Registration and Setup
10:30 - 10:40 AM
Welcome and introduction
10:40 - 10:50 AM
Introductory remarks and USEPA perspective
10:50 - 11:00 AM
Introductory remarks and EOHSI perspective
11:00 - 11:45 AM
A multiscale framework for environmental systems toxicology
11:45 - 12:30 PM
The Virtual Liver Project: Modeling tissue response to chemicals through multiscale simulation
12:30 - 01:30 PM
01:30 - 02:15 PM
Genetic and environmental pathways to complex diseases
02:15 - 03:00 PM
Dissecting flux changes in mammalian cells: Application to understanding viral infection
03:00 - 03:45 PM
The Virtual Embryo Project (v-EmbryoTM)
03:45 - 04:00 PM
04:00 - 04:45 PM
Computational modeling of liver function
04:45 - 05:30 PM
Computational toxicology: New methods and models at the molecular level
05:30 - 06:30 PM
Highlight “Gene expression studies of mouse skin response to sulfur mustard exposure for
evaluating efficacy of inhibitors”
Dr. Donald R. Gerecke, UMDNJ/Rutgers University CounterACT Research Center of Excellence
06:30 - 07:30 PM
07:30 - 08:15 PM
Keynote Address: There is no place like "-ome"
Thursday, May 1
08:30 - 09:00 AM
09:00 - 09:45 AM
The EPA ToxCast Program
09:45 - 10:15 AM
Toxicogenomics: Technology, application and challenges
10:15 - 10:30 AM
10:30 - 11:15 AM
Computational toxicology from a cheminformatics perspective
11:15 - 12:00 PM
Discovery in proteomics: De novo and hybrid methods via tandem mass spectrometry
12:00 - 01:30 PM
Lunch and Poster Session
01:30 - 02:15 PM
From data to models: Systems toxicology linkages to toxicoinformatics
02:15 - 03:15 PM
Concluding remarks and adjournment
4/29/2008; 12:00 pm, Disha Patel, Ernest Mario School of Pharmacy, ‘Structure-activity relationships by NMR: an approach to fragment based drug design’; room 323A, Pharmacy building, Busch campus.
4/21/08; 12:00 pm; San Ming Wang, Feinberg School of Medicine, Northwestern University, Evanston, IL, "Studying Human Genome Structure at Kilobase Resolution"
Normal genome variation and pathogenic genome alteration frequently affect small regions in the genome. We have developed the DGS (Ditag Genome Scanning) platform for kilobase-resolution analysis of genome structure. Analyzing five normal and cancer genomes using this platform reveals new patterns of normal genome variation and cancer genome mutation.
4/16/08; 12:00 pm; Sherif Ibrahim, Rutgers School of Pharmacy, ‘The Warburg effect and glycolysis inhibition’, Pharmacy, room 007, Busch campus.
4/14-4/16 - CounterACT Annual progress meeting, Embassy Suites, 900 10th St. NW, Washington D.C..
4/14/08; 12:00 pm; Dr. Titia de Lange, Rockefeller University, “Protein complexes that shape and safe-guard human telomeres”; Waksman Institute, Busch campus, Rutgers University.
4/11/08; 1:30 pm; Sung Hack Lee, Pharmaceutical Sciences, Rutgers University, “Characterizing the mechanism of differential pharmacokinetic disposition of two structurally similar nucleosides”; room 007, School of Pharmacy Building.
4/11/08; 12:00 pm, Michael B. Weinstein, Ph.D., Ohio State University, "Functions of TGF-beta signaling in development and diseases", Room B228, Nelson Labs, Busch campus, Piscataway, NJ
4/9/08, 3 pm, Nobel Laureate Dr. Matthew Meselson; Harvard University, "Mechanisms of cell replication", UMDNJ-RWJMS, main auditorium, Piscataway, NJ
4/9/08; 12:00 pm, Zedong Dong, Ph.D., Hoffman-La Roche, “Applications of physico-chemical characterization in drug development”, room 007, Rutgers University School of Pharmacy, Busch campus, Piscataway.
4/08/08; David J. Moore, Ph.D., International Specialty Products, Wayne, NJ, “Spectroscopy, Microscopy and Imaging of the Skin Barrier”, EOHSI Building, Rutgers Busch campus, Piscataway, NJ.
4/08/08, 4:00 pm; CounterACT is participating in the UMDNJ-Robert Wood Johnson Medical School Center for Clinical and Translational Sciences Symposium
“Validation of Scientific Discoveries in Humans", CABM 010, Rutgers Busch campus, Piscataway, NJ Program:
Moderator: Céline Gélinas, PhD, Professor of Biochemistry
UMDNJ-Robert Wood Johnson Medical School
Center for Advanced Biotechnology and Medicine
The Cancer Institute of New Jersey
Presentation 1: “Prostate Tumor Tissue Explant System for Therapeutic Validation”
Eileen White, PhD, Professor of Molecular Biology and Biochemistry
Rutgers, The State University of New Jersey
Center for Advanced Biotechnology and Medicine
The Cancer Institute of New Jersey
The Cancer Institute of New Jersey Tissue Retrieval Service:
Presentation 2: “The Cancer Institute of New Jersey Tissue Retrieval Service”
David A. August, MD, Professor of Surgery
UMDNJ-Robert Wood Johnson Medical School
Chief, Surgical Oncology
The Cancer Institute of New Jersey
Presentation 3: “Studying Common Human Genetic Disorders: DNA and Tissue Samples”
Jim Millonig, PhD, Assistant Professor of Neuroscience & Cell Biology
UMDNJ-Robert Wood Johnson Medical School
Center for Advanced Biotechnology and Medicine
Human Cell Lines as Model Systems for Research
Linda Brzustowicz, MD, Professor of Genetics
Rutgers, The State University of New Jersey
Presentation 4: “Regulatory Perspectives to Consider in the Research Use of Stored Data or Tissues”
Donna Hoagland, LPN, BS, CIP, CCRC
Director, UMDNJ Institutional Review Board
New Brunswick/Piscataway & Stratford Campuses
Presentation 5 ”Studying Common Human Genetic Disorders: DNA and Tissue Samples”
Jim Millonig, PhD, Assistant Professor of Neuroscience & Cell Biology
UMDNJ-Robert Wood Johnson Medical School
Center for Advanced Biotechnology and Medicine
Presentation 6: “Human Cell Lines as Model Systems for Research”
Linda Brzustowicz, MD, Professor of Genetics
Rutgers, The State University of New Jersey
Presentation 7: “Regulatory Perspectives to Consider in the Research Use of Stored Data or Tissues”
Donna Hoagland, LPN, BS, CIP, CCRC
Director, UMDNJ Institutional Review Board
New Brunswick/Piscataway & Stratford Campuses
4/3/08 - CounterACT Center meeting, 2-4 pm, 402 EOHSI.
4/02/08; 12:00 pm; Yong-Hae Han, Ph.D., Bristol-Myers Squibb, “Transporter Phenotyping in Drug Discovery”, room 007, Rutgers School of Pharmacy, Busch campus, Piscataway, NJ
3/27/08; 3:00 pm; Debra Laskin, Rutgers School of Pharmacy, ‘The lung as a target for sulfur mustard toxicity’, EOHSI, 402, Busch campus.
3/26/08, 3 pm; Dr. David L. Rimm, Yale University School of Medicine, "Biomarker discovery by quantitative and multiplexed analysis of tissue microarrays", CINJ auditorium
3/25/08; 1:30 pm; Glenn Paulson, Ph.D., UMDNJ School of Public Health, Chemical control: near miss disasters; EOHSI A&, Busch campus, Rutgers, Piscataway, NJ
3/21/08; 12:00 pm, William Marzluff, Ph.D., University of North Carolina at Chapel Hill, “Novel mechanisms in histone mRNA metabolism; Room B228, Nelson Labs, Busch campus, Piscataway.
3/16/08 - 3/20/08 - Society of Toxicology National Meeting in Seattle, WA. Many individuals from our Center will be presenting research at this symposium.
3/16/08-3/19/08 - International Conference on Emerging and Infectious Diseases. Atlanta, GA. [link]
3/14/08 - Symposium: “Wound Healing and Tissue Engineering” 2:30-4:00 pm. Room 120 Busch Campus Center.
Sheila Macneil, Ph.D., Professor of Tissue Engineering, University of Sheffield in the UK
Research interests: Progress and opportunities for tissue-engineered skin
Ewa Herbst, Ph.D., President and CEO, Herbst Research, Edgewater, NJ
Research interests: Use of electric fields to stimulate tissue healing and regeneration
Michael Jaffe, Ph.D., Research Professor Biomedical Engineering, NJIT
Research interests: Development of novel biomaterials for wound healing
Ramsey Foty, Ph.D., Assistant Professor of Surgery, UMDNJ-RWJMS
Research interests: Cell-cell cohesion and cell-substratum adhesion in tissue-biomaterial interaction
Charles Gatt, M.D., Chair of Orthopaedics, UMDNJ-RWJMS
Research interests: Clinical perspectives on tissue engineering
Debabrata Banerjee, Ph.D., Associate Professor, Medicine and Pharmacology, UMDNJ-RWJMS
Research interests: Stem cells in wound healing and regeneration
3/12/08; 12 pm; Dr. Elaine Ostrander, NIH, “Genetic Mapping of Complex Traits” CABM 010, Rutgers Busch campus, Piscataway, NJ
3/12/08; 12:00 pm; Anjaneya Chimalakonda, Ph.D., Bristol-Myers Squibb, Pharmacokinetic/pharmacodynamic models to predict drug efficacy following short term therapy”, room 007, Rutgers School of Pharmacy, Piscataway, NJ
3/10/08; 12 pm; Dr. Rajesh Ranganathan, Novartis Institutes for BioMedical Research, “Drug Discovery Challenges”, Auditorium, Rutgers Life Sciences Bldg, Busch campus, Piscataway, NJ
3/5/08; 5:00 pm, Louis J. Lombardo, Ph.D., Director, Oncology Chemistry, Bristol-Myers Squibb, Lawerenceville, NJ, “Preclinical studies with a potent multi-targeted kinase inhibitor”, Rutgers School of Pharmacy, room 007, Busch campus
3/3/08; 12 pm; Jianjie Ma, Ph.D., UMDNJ-Robert Wood Johnson Medical School, Calcium transients in cell growth regulation, V10 UMDNJ, Busch campus, Piscataway, NJ
2/25/08; 12 pm; Thomas Scanlin, M.D., UMDNJ-RWJMS, ‘Therapeutic Implication of Altered Glycosylation’; Robert Wood Johnson Medical School, Piscataway, NJ, Busch campus, room V10.
2/26/08 - Richard Carthew Northwestern University Mechanism and Biology of Small Regulatory RNAs Tuesday, February 26, 2008 16:00 Waksman Auditorium
2/24/08-2/27/08 - 6th Annual ASM Biodefense and Emerging Diseases Research Meeting, Baltimore, MD. [link]
2/21/08; 12:00 pm; Joan Durbin M.D., Ph.D., Ohio State University College of Medicine, Rodent models of human airway disease, CABM 010, Piscataway, NJ
2/20/08; 4 pm; David Williams, M.D. Children's Hospital Boston, Rac and Rho H as mediators of cell growth regulation; CINJ Auditorium, New Brunswick, NJ
2/18/08; 12 noon, Carlo Croce, MD, Ohio State University Comprehensive Cancer Center, "Role of microRNAs in cell growth regulation", Auditorium A, Cancer Institute of New Jersey, New Brunswick, NJ
2/18/2008; 12:00 pm, William J. Welsh, Ph.D., Dept. Molecular and Cellular Pharmacology, UMDNJ-Robert Wood Johnson Medical School; “Computational Approaches to Drug Discovery”, second floor conference room, Laboratory for Cancer Research, Rutgers School of Pharmacy, Busch campus, Piscataway, NJ
2/15/08; 12:00 pm; Iannis Aifantis, Ph.D., New York University School of Medicine, Regulation of stem cell self-renewal by the ubiquitin ligase Fbw7; Nelson B228, Busch campus, Rutgers, Piscataway, NJ
2/11/08 - Alexandra C. Newton, Ph.D., Professor, Department of Pharmacology, UCSD. "Signal Termination: PHLiPPing the Switch in Akt and Protein Kinase C Signaling", 12pm, Room V-10, RWJMS, New Brunswick, NJ.
2/7/08 - CounterACT Center meeting, 2-4 pm, 402 EOHSI.
2/7/08 - Marcia Slater, Ph.D., Applied Biosystems; “Real-Time PCR without RNA purification from Cells”, CINJ Main Auditorium, New Brunswick, NJ
2/6/08, 4 PM; Peter P. Tolias, Ph.D., New Jersey Medical School, Translational Research at the Institute of Genomic Medicine, CINJ, Main Auditorium
2/06/2008; Dr. David Botstein, Princeton University, “Transcriptional and physiological responses to differences in growth rate”; 12:00 CABM 010
1/29/08, 11:00 a.m., Dr. Tatiana Bronich, University of Nebraska Medical Center; "Polymer micelles as nanocarriers for drugs and imaging age" Chemistry Bldg seminar room, Busch campus, Piscataway, NJ
1/29/08 - Dr. Gregory Hannon Cold Spring Harbor Laboratory Conserved roles of small RNAs in genome defense Tuesday, January 29, 2008 12:00 CABM 010
1/28/08 - Dr. Paul McNeil, Medical College of Georgie, "Cell Membrane Repair", 12pm, RWJMS Piscataway, Room V10.
1/22/08; Max Garzon, Ph.D., Computer Science, The University of Memphis, “Synthetic Biology for Bioinformatics” 3:30 pm, Room 402, EOHSI, RWJ Medical School, Busch Campus, Piscataway, N.J.
1/18/08 - Dr. Yufang Shi, "Regulation of Immune Responses by AICD and Stem Cells"; CABM, Room 010, 9:30am
1/14/2008; Dr. Rajesh Ranganathan, Novartis Institutes for BioMedical Research, ‘Meeting the drug discovery challenge’;12:00 Genetics Inst. Auditorium
1/11/08; 12:00 pm, Dr. Guy Werlen, Rutgers University, “Role of ERK signaling in T lymphocyte development”, Room B228, Nelson Labs, Busch campus, Piscataway, NJ
1/10/08 - External Advisory Committee Board meeting, EOHSI Conference Room C, 8:30am to 5 pm. Drs. Carl Baker and David Jett will be attending.
1/9/08 - Dr. David Jett, National Institute of Health - NINDS, "Counterterrorism Research at the National institutes of Health"; 4pm, EOHSI conference room C.
1/8/08 - CounterACT Center meeting, 2-4 pm, 402 EOHSI.
1/7/2008; 2:00 PM; Noon; Cancer Center Building - G1196, "Identification of steps in cell cycle progression of normal and cancer cells controlled by Rho GTPases”, Alan Hall, Ph.D., Chair, Cell Biology Program, Memorial Sloan-Kettering Cancer Center
1/3/08 - Dr. Peter James O'Dwyer, M.D., Professor of Medicine, "Translational studies on the targeting of anti-angiogenesis drugs". Thursday, January 3, 2008, 12pm, CABM 010.
12/19/07 - Mary-Ann Bjornsit, Ph.D. St. Jude's Children Research Hospital TOR Signaling in S-phase Wednesday, December 19, 2007 16:00 CINJ Auditorium
12/18/07, Yury S. Polikanov, Department of Pharmacology, UMDNJ-Robert Wood Johnson Medical School, Mechanims of Communication over a Distance on DNA and Chromatin, 12:00 NOON, RWJMS, room V-10, Piscataway
12/17/07; Yong Wan, Ph.D. Cell Biology and Physiology, University of Pittsburgh, School of Medicine "Control of the cell cycle"; 2:00 pm, RWJMS-Room V10, Piscataway, NJ
11/30/07 - Debra L. Laskin, Department of Pharmacology & Toxicology, Rutgers University, Role of Inflammatory Mediators in Sulfur Mustard-induced Lung Injury, 2:00 pm, EOHSI building, conference room C, Piscataway
11/28/07 - Thermodynamics of Force-Induced DNA-ligand Interactions" - Mark C. Williams, Northeastern University. 1:30 pm at 260 Hill Center (Busch Campus).
11/20/07 - "Coordinating DNA repair with cell cycle progression" -Matthew O'Connell, Ph.D., Mount Sinai School of Medicine. 12pm at 10 CABM, RWJMS.
11/15/07; Dr. Thomas Kensler, Johns Hopkins University “Mechanisms of cellular responses to oxidative stress”, 2:00 P.M. seminar; EOHSI Building room C, Busch campus of Rutgers University,
11/15/07; Nobel Laureate Dr. Robert H. Grubbs, Caltech, ‘Synthesis of large and small molecules using olefin metathesis catalysts’, 4 pm Wright Laboratory, Busch Campus, Rutgers University
11/14/07 - Dr. Jeffrey D. Laskin, UMDNJ-Robert Wood Johnson Medical School; 2:00 P.M. plenary talk for the Dermal Clinical Evaluation Society; “Developing skin active agents against sulfur mustard: The Rutgers/UMDNJ CounterACT Research Center of Excellence”; Teaneck Marriott, Teaneck, NJ
11/6/07 - Robert Ross, Department of Homeland Security, "Managing Homeland Security Risk: A New Approach", 5-6pm, DIMACS Center, CoRE Bldg 431, Rutgers, Piscataway, NJ.
11/6/07 - Rashmi Thakur - "Design of Polymeric drug delivery system providing targeted drug release profiles of hydrophilic and lipophilic compounds." 10am-12pm, 202, Laboratory for Cancer Research.
11/5/07-11/7/07 - 2007 Biodefense Research Conference. Bridging the gap: Biodefense and Beyond. Philadelphia, PA. [link]
10/24/07 "Method Development and Validation Strategies for Quantitative LC/MS/MS" - Wei Zhou, Ph.D., Lab Head, Drug Metabolism & Bioanalytics, Novarti. Room 007, Pharmacy Building, 12-1:30pm.
10/23/07 - "Models of Gene Regulation" - Tomas Gedeon, Montana State University. 12 pm in 260 Hill Center (Busch Campus).
10/17/07 - "The Future of Genomic Medicine: From Dr. Freud to Dr. McCoy" - Edward Russel Dougherty, Texas A&M University. 1:30pm at 260 Hill Center (Busch Campus).
10/16/07 - "Hydrophobic Hydration at the Nanoscale" - Peter Rossky, University of Texas at Austin. 11 am, Wright-Reiman Auditorium (Busch Campus).
10/17/7 - The UMDNJ/Rutgers University CounterACT Center Research Center of Excellence is participating in a Preparedness Symposium on issues in Terrorism organized by the New Jersey Preparedness Training Consortium to be held at the Rutgers University School of Pharmacy in Piscataway, NJ, October 17, 2007 [registration]
When Terrorism Strikes - How a Pharmacist can Save the World"
8:15 – 8:30 Welcome and Introduction (Dr. Benjamin Chavez, Rutgers University School of Pharmacy, NJ)
8:30 – 9:30 New Developments in Bioterrorism Agents (Dr. Clifton Lacy, UMDNJ-Robert Wood Johnson Medical School, NJ)
9:30 -10:30 Chemical Agents in Terrorism (Dr. Kevin Rynn, Rutgers University School of Pharmacy, NJ)
10:45-11:35 Psychology of Bioterrorism (Dr. Sajjad Zaidi, Monmouth Medical Center, NJ)
12:45-1:35 Command and Control (Dr. Joseph Barone, Rutgers University School of Pharmacy, NJ)
1:35-2:25 Pharmacist’s Role and Response (Mr. Richard Palombo, Medco Health Solutions, NJ)
2:40-3:30 Application of Legal Issues During a Bioterrorism Event (Dr. Angelo Cifaldi, Rutgers University School of Pharmacy, NJ)
3:30-3:45 Questions and Evaluation
10/8/07-10/10/07 - Defense Against the Effects of Chemical Hazards: Toxicology, Diagnosis, and Medical Countermeasures, Edinburgh, Scotland. Sponsored by the Research and Technology Organization of the North Atlantic Treaty Organization. [link]
10/10/07 - "The Role of Sequence-specific DNA Structure in Gene Regulation" - Remo Rohs, Columbia University. 1:30pm, 260 Hill Center (Busch Campus).
8/31/07 - 9am-1pm - "Rehearsals for CounterACT External Advisory Committee", Piscataway, NJ
8/28-8/30 - "CounterACT Research Center Symposium on Exposures to Highly Toxic Chemicals", Piscataway, NJ (Drs. Joshua Gray and Diane E. Heck, program coordinators)
8/27/07 - 12pm-4pm; Preparation and Evaluations for the Fall 2007 - Spring 2008 CounterACT Course Programs sponsored by the CounterACT Research and Training Core (Drs. Joshua P. Gray and Diane E. Heck, Core Directors), Piscataway, NJ
8/16/07 - Annual UMDNJ/Rutgers University CounterACT Center retreat. 216 Lillie Building, Marine Biological Laboratory, Woods Hole, MA. 12pm-4pm.
7/29/2007-8/4/2007 - Data Analysis in Law Enforcement and Homeland Security. This Summer Reconnect Conference sponsored by DyDAn (The Homeland Security Center for Dynamic Data Analysis). [link]
6/25-6/27 - Statistical Analysis of Analytical Data. Summer short-course, New Brunswick, NJ. [link]
6/26-6/28 - Experimental Design for Productivity & Quality in R&D. Summer short-course, New Brunswick, NJ. [link]
6/20/07 - Symposium on Modeling for Exposures to Highly Toxic Chemicals. Sponsors: American Chemistry Council and EOHSI Chemical Chemodynamics Laboratory. Rutgers University, EOHSI building, 9am-5pm, Conference Room C, Piscataway, NJ.
Topics and Speakers: ' Inhalation Exposure Modeling’ Panos Georgopoulos, UMDNJ; ‘Exposure Research and Modeling at the EPA’, John Langstaff, Janet Burke, USEPA; ‘New Jersey Department of Environmental Protection Air Monitoring Network’, Linda Bonanno, NJDEP; ‘Modeling Population Exposures, Sastry Isukapalli, EOHSI; ‘Developing Exposure Databases’; Cliff Weisel, Shang-Wei Wang; EOHSI.
6/16/07 - 10:30 AM-4:00 PM, TriState CACS 2007 Annual Symposium co-sponsored by the Department of Pharmaceutical Sciences, Rutgers University School of Pharmacy, “Chemistry Frontiers, Challenges and Opportunities”, A symposium on the development of small molecules by the pharmaceutical industry including drug screening and lead optimization (www.tristatecacs.org), Rutgers University Fiber Optic Auditorium, Busch Campus, Piscataway, NJ
6/14/07 - Andrew Gow, Ph.D., Associate Professor, Department of Pharmacology & Toxicology, Ernest Mario School of Pharmacy, Rutgers University. "Nitric oxide and innate immunity: how do we get so much from so little?" 11:30am, Laboratory of Cancer Research, Rutgers School of Pharmacy.
6/1/2007 - Joshua P. Gray, Ph.D., UMDNJ-Rutgers University CounterACT Research Center of Excellence. "Chemical Terrorism: the lung as a target." Sponsored by the New Jersey Thoracic Society. 10 am, Room 1302, Clinical Academic Building, UMDNJ-Robert Wood Johnson Medical School.
5/31/2007-6/1/2007 - Workshop: The Mathematics of Homeland Security: Topics for High School Teachers. DIMACS Center - Rutgers. [link]
5/23/2007-5/24/2007 - The IEEE International Conference on Intelligence and Security Informatics 2007. Hyatt Hotel, New Brunswick, NJ. Dr. Jeffrey D. Laskin, P.I. for the UMDNJ/Rutgers University CounterACT Research Center of Excellence will participate in a panel on “Preparedness for and Response to High-Consequence Events” that will be moderated by Dr. Paul J. Lioy, Professor and Deputy Director of the Environmental and Occupational Health Sciences Institute at UMDNJ/Rutgers University [link]
5/11/2007 - Leonard A. Cole, Ph.D, Rutgers University, Newark. "Terror Medicine" 12:30pm, Room 280, Carl Icahn Laboratory, Princeton, NJ.
5/4/2007 - Jonathan B. Chaires, Ph.D. "Five Decades (almost) of Drug-DNA Interactions." 12pm at the Fiber Optics Auditorium, Busch Campus, Rutgers University.
5/4/2007 - Arturo Casadevall, Ph.D., Yeshiva University. "The Weapon Potential of a Microbe and the Select Agents Act". 12:30pm, Room 280, Carl Icahn Laboratory, Princeton, NJ.
5/3/2007 - Daniel Krewsski, Ph.D., Institute of Population Health, University of Ottawa. "Population Health Risk Assessment". 12pm, Conference Room C, EOHSI Building, Busch Campus, Rutgers University, Piscataway, NJ.
4/27/2007 - The Environmental Bioinformatics and Computational Toxicology Center at Rutgers is sponsoring a "Systems Toxicology" full day workshop, from 8:30am - 3:30pm at the CoRE Building Auditorium, Rutgers Busch Campus. For information, register here.
4/25/2007-4/27/2007 - The first annual CounterACT Network Research Symposium will take place from April 25-27 in Arlington VA. This meeting will facilitate information sharing and collaboration between investigators in the CounterACT Network and serve as a progress evaluation for the NIH. For news and information on registration for the CounterACT - Countermeasures Against Chemical Terrorism Annual meeting, see here [link].
4/24/07 - Thomas H. Rushmore, Ph.D., Drug Metabolism (Preclinical), Merck Research Laboratory, West Point, PA. "Application of pharmacogenetics in drug discovery and development: experiences in drug metabolism" Room 323A, Rutgers School of Pharmacy, 12pm.
4/11/2007-4/12/2007 - Short Course: A Field Guide to Gen Bank and NCBI Molecular Biology Resources. DIMACS Center - Rutgers. [link]
4/6/2007 - Robert P. Casillas, Ph.D., Deputy Director, Battelle Biomedical Research Center, Battelle Memorial Institute, Columbus, OH, April 6, 12:30, EOHSI room 402 “Mechanism of action of sulfur mustard”.
4/2/2007 - Dr. Helmut Zarbl, Ph.D., UMDNJ-Robert Wood Johnson Medical School, "Using Aptamer Arrays to Identify Biomarkers of Chemical-induced Toxicity." EOHSI, Room 402, 12pm.
3/26/2007 - Mitchell D. Erickson, Ph.D., US Department of Homeland Security. Issues in Critical Infrastructure Protection, 10am, UMDNJ-School of Public Health, Room 3A-B, Piscataway, NJ. "Dr. Erickson is a widely recognized expert on both chemical and radiological threats. His talk will present the overarching needs to protect our nation’s infrastructure, and how the federal government is structured to meet these needs."
3/14/2007 - Panos Georgopoulos, Ph.D., Optimization tools for in silico proteomics, 12pm, EOHSI Conference Room C, Rutgers University, Busch Campus, Piscataway, NJ.
3/9/2007 - Drew Endy, Ph.D., Assistant Professor, Biological Engineering, MIT. "Synthetic Biology and Biological Security" 12:30pm, Room 280, Carl Icahn Laboratory, Princeton, NJ.
3/1/2007 - Dana Barr, Ph.D., Toxicology Branch, Division of Laboratory Sciences, Centers for Disease Control. “Assessing Exposure Using Biomonitoring” 12pm, EOHSI Building, conf room C, Rutgers University, Busch Campus, Piscataway, NJ.
2/27/2007 - Seminar: "Challenges in Targeting Actives to the Skin", Bozena B. Michniak-Kohn, Ph.D., M.R., Pharm. S., Conference Room C, EOHSI Building, Rutgers University, Piscataway, NJ.
2/26/2007 - Opening of the new Department of Homeland Security "Center of Excellence" for Dynamic Data Analysis, 2:30-5:30 pm, CoRE Building, Busch Campus, Rutgers University, Piscataway, NJ. Also includes a presentation on DHS research problems at the Lawrence Livermore National Laboratory and a keynote address on data privacy by Steven Fienman of Carnegie-Mellon University.
1/26/07 - Documentation and Regulatory Requirements for Pharmaceutical Development - Noreen Sinko, Department of Pharmaceutics, Rutgers University School of Pharmacy. 12-1pm, 007, Pharmacy Building, Rutgers University.
1/10/07 - New Rutgers Pharmaceutical Engineering course offering: "Pharmaceutical Organic Nanotechnology (16:155:544): this course provides an introduction to organic nanotechnolgoy and experimental design methods and their applications to designing and manufacturing drug products for the pharmaceutical industry.
12/13/2006 - William Welsh, Ph.D., Cheminformatics Tools for Toxicant Identification and Characterization, EOHSI, Conference Room C, Rutgers University, 12pm.
10/31/06 - Low surfactant delivery systems based upon sucrose ester emulsifiers - Paul Thau, Pa Car Tech, Berkeley Heights, NJ. 12:30 pm-1:30 pm, Conference Room C, EOHSI, Rutgers University.
10/26/06 - Laminin-332 and MMP-9 upregulation in wounded mouse skin - Donald Gerecke, Ph.D.
3-4:30pm, Seminar Room, Lab for Cancer Research, Rutgers University.
The UMDNJ/Rutgers University Counter Center is a collaboration between: