Vesicants Reference Library
Literature on vesicating agents may provide important clues that will lead to the development of effective countermeasures. The Vesicants Reference Library supports searches using filters, and citations can be downloaded directly into EndNote and other popular literature citation formats.
CounterACT Research Products: Recent Publications by the Rutgers CounterACT Center Investigators
, 2019. Hydroxyl Radicals in E-Cigarette Vapor and E-Vapor Oxidative Potentials under Different Vaping Patterns. Chem Res Toxicol.
, 2019. Anandamide down-regulates placental transporter expression through CB2 receptor-mediated inhibition of cAMP synthesis. Pharmacol Res 141:331-342
, 2019. Methyl isocyanate inhalation induces tissue factor-dependent activation of coagulation in rats. Drug Chem Toxicol 42(3):321-327
, 2019. Synthetically modified methoxsalen for enhanced cytotoxicity in light and dark reactions. Bioorg Med Chem Lett 29(4):619-622
, 2018. An Engineered Human Fibroblast Growth Factor-1 Derivative, TTHX1114, Ameliorates Short-term Corneal Nitrogen Mustard Injury in Rabbit Organ Cultures. Invest Ophthalmol Vis Sci 59(11):4720-4730
, 2018. Quinone and nitrofurantoin redox cycling by recombinant cytochrome b5 reductase. Toxicol Appl Pharmacol 359:102-107
, 2018. Expression of Laminin 332 in Vesicant Skin Injury and Wound Repair. Clin Dermatol (Wilmington) 2.
, 2018. Expression of cytokines and chemokines in mouse skin treated with sulfur mustard. Toxicol Appl Pharmacol 355:52-59
, 2018. Nanotherapeutics Containing Lithocholic Acid-Based Amphiphilic Scorpion-Like Macromolecules Reduce In Vitro Inflammation in Macrophages: Implications for Atherosclerosis. Nanomaterials (Basel) 8.
, 2018. Sulfur mustard induced mast cell degranulation in mouse skin is inhibited by a novel anti-inflammatory and anticholinergic bifunctional prodrug. Toxicol Lett 293:77-81
, 2017. World Trade Center (WTC) dust exposure in mice is associated with inflammation, oxidative stress and epigenetic changes in the lung. Exp Mol Pathol 102(1):50-58
, 2017. Editor's Highlight: Role of Spleen-Derived Macrophages in Ozone-Induced Lung Inflammation and Injury. Toxicol Sci 155(1):182-195
, 2017. Editor's Highlight: CCR2 Regulates Inflammatory Cell Accumulation in the Lung and Tissue Injury following Ozone Exposure. Toxicol Sci 155(2):474-484
, 2017. Regulation of Nitrogen Mustard-Induced Lung Macrophage Activation by Valproic Acid, a Histone Deacetylase Inhibitor. Toxicol Sci 157(1):222-234
, 2017. Biodegradable Kojic Acid-Based Polymers: Controlled Delivery of Bioactives for Melanogenesis Inhibition. Biomacromolecules 18(2):363-373
, 2017. Athero-inflammatory nanotherapeutics: Ferulic acid-based poly(anhydride-ester) nanoparticles attenuate foam cell formation by regulating macrophage lipogenesis and reactive oxygen species generation. Acta Biomater 57:85-94
, 2017. Diacetyl/l-Xylulose Reductase Mediates Chemical Redox Cycling in Lung Epithelial Cells. Chem Res Toxicol 30(7):1406-1418
, 2017. Anti-TNFα therapy in inflammatory lung diseases. Pharmacol Ther 180:90-98
, 2016. The spleen as an extramedullary source of inflammatory cells responding to acetaminophen-induced liver injury. Toxicol Appl Pharmacol 304:110-20
, 2016. Characterization of Distinct Macrophage Subpopulations during Nitrogen Mustard-Induced Lung Injury and Fibrosis. Am J Respir Cell Mol Biol 54(3):436-46
, 2016. China and the United States--Global partners, competitors and collaborators in nanotechnology development. Nanomedicine 12(1):13-9
, 2016. Inflammatory mechanisms of pulmonary injury induced by mustards. Toxicol Lett 244:2-7
, 2016. Selective Targeting of Heme Protein in Cytochrome P450 and Nitric Oxide Synthase by Diphenyleneiodonium. Toxicol Sci 151(1):150-9
, 2016. The Effect of Diet and Exercise on Intestinal Integrity and Microbial Diversity in Mice. PLoS One 11(3):e0150502
, 2016. ADAM17 Inhibitors Attenuate Corneal Epithelial Detachment Induced by Mustard Exposure. Invest Ophthalmol Vis Sci 57(4):1687-98
, 2016. Mustard vesicants alter expression of the endocannabinoid system in mouse skin. Toxicol Appl Pharmacol 303:30-44
, 2016. Preparedness and response to chemical and biological threats: the role of exposure science. Ann N Y Acad Sci 1378(1):108-117
, 2016. Mitigation of nitrogen mustard mediated skin injury by a novel indomethacin bifunctional prodrug. Exp Mol Pathol 100(3):522-31
, 2016. Mustard vesicant-induced lung injury: Advances in therapy. Toxicol Appl Pharmacol 305:1-11
, 2016. Macrophages and inflammatory mediators in pulmonary injury induced by mustard vesicants. Ann N Y Acad Sci 1374(1):168-75
, 2016. Concerted action of IFN-α and IFN-λ induces local NK cell immunity and halts cancer growth. Oncotarget 7(31):49259-49267
, 2016. Tissue injury and repair following cutaneous exposure of mice to sulfur mustard. Ann N Y Acad Sci 1378(1):118-123
, 2016. Multidisciplinary approaches to stimulate wound healing. Ann N Y Acad Sci 1378(1):137-142
, 2016. Novel approaches to mitigating parathion toxicity: targeting cytochrome P450-mediated metabolism with menadione. Ann N Y Acad Sci 1378(1):80-86
, 2016. Multi-inhibitor prodrug constructs for simultaneous delivery of anti-inflammatory agents to mustard-induced skin injury. Ann N Y Acad Sci 1378(1):174-179
, 2016. The molecules in the corneal basement membrane zone affected by mustard exposure suggest potential therapies. Ann N Y Acad Sci 1378(1):158-165
, 2015. Sulfa drugs inhibit sepiapterin reduction and chemical redox cycling by sepiapterin reductase. J Pharmacol Exp Ther 352(3):529-40
, 2015. Combined diazepam and MK-801 therapy provides synergistic protection from tetramethylenedisulfotetramine-induced tonic-clonic seizures and lethality in mice. Neurotoxicology 48:100-8
, 2015. Radiation-induced lung injury and inflammation in mice: role of inducible nitric oxide synthase and surfactant protein D. Toxicol Sci 144(1):27-38
, 2015. Sugar-based amphiphilic nanoparticles arrest atherosclerosis in vivo. Proc Natl Acad Sci U S A 112(9):2693-8
, 2015. Regulation of ozone-induced lung inflammation and injury by the β-galactoside-binding lectin galectin-3. Toxicol Appl Pharmacol 284(2):236-45
, 2015. Responsive foams for nanoparticle delivery. Colloids Surf B Biointerfaces 133:81-7
, 2015. Single-Step Assembly of Multimodal Imaging Nanocarriers: MRI and Long-Wavelength Fluorescence Imaging. Adv Healthc Mater 4(9):1376-85
, 2015. Attenuation of Nitrogen Mustard-Induced Pulmonary Injury and Fibrosis by Anti-Tumor Necrosis Factor-α Antibody. Toxicol Sci 148(1):71-88
, 2015. Thioredoxin Cross-Linking by Nitrogen Mustard in Lung Epithelial Cells: Formation of Multimeric Thioredoxin/Thioredoxin Reductase Complexes and Inhibition of Disulfide Reduction. Chem Res Toxicol 28(11):2091-103
, 2015. Ethynylphenyl carbonates and carbamates as dual-action acetylcholinesterase inhibitors and anti-inflammatory agents. Bioorg Med Chem Lett 25(23):5609-12
, 2015. A Novel High-Throughput Approach to Measure Hydroxyl Radicals Induced by Airborne Particulate Matter. Int J Environ Res Public Health 12(11):13678-95
, 2014. Critical role of the endogenous interferon ligand-receptors in type I and type II interferons response. Immunology 142(3):442-52
, 2014. Regulation of keratinocyte expression of stress proteins and antioxidants by the electrophilic nitrofatty acids 9- and 10-nitrooleic acid. Free Radic Biol Med 67:1-9
, 2014. Pharmaceutical and toxicological properties of engineered nanomaterials for drug delivery. Annu Rev Pharmacol Toxicol 54:581-98
, 2014. Oxidative stress-induced autophagy: role in pulmonary toxicity. Toxicol Appl Pharmacol 275(2):145-51
, 2014. Gelation chemistries for the encapsulation of nanoparticles in composite gel microparticles for lung imaging and drug delivery. Biomacromolecules 15(1):252-61
, 2014. Modulation of keratinocyte expression of antioxidants by 4-hydroxynonenal, a lipid peroxidation end product. Toxicol Appl Pharmacol 275(2):113-21
, 2014. Acute chlorine gas exposure produces transient inflammation and a progressive alteration in surfactant composition with accompanying mechanical dysfunction. Toxicol Appl Pharmacol 278(1):53-64
, 2014. Cross-linking of thioredoxin reductase by the sulfur mustard analogue mechlorethamine (methylbis(2-chloroethyl)amine) in human lung epithelial cells and rat lung: selective inhibition of disulfide reduction but not redox cycling. Chem Res Toxicol 27(1):61-75
, 2014. Acetaminophen reactive intermediates target hepatic thioredoxin reductase. Chem Res Toxicol 27(5):882-94
, 2014. Structural changes in hair follicles and sebaceous glands of hairless mice following exposure to sulfur mustard. Exp Mol Pathol 96(3):316-27
, 2014. Differential metabolism of 4-hydroxynonenal in liver, lung and brain of mice and rats. Toxicol Appl Pharmacol 279(1):43-52
, 2014. Pentoxifylline attenuates nitrogen mustard-induced acute lung injury, oxidative stress and inflammation. Exp Mol Pathol 97(1):89-98
, 2014. Human recombinant cytochrome P450 enzymes display distinct hydrogen peroxide generating activities during substrate independent NADPH oxidase reactions. Toxicol Sci 141(2):344-52
, 2014. Agents of Bioterrorism: Curriculum and Pedagogy in an Online Masters Course. J Toxicol Educ 1:31-53
, 2014. Therapeutic potential of a non-steroidal bifunctional anti-inflammatory and anti-cholinergic agent against skin injury induced by sulfur mustard. Toxicol Appl Pharmacol 280(2):236-44
, 2014. Optimal structural design of mannosylated nanocarriers for macrophage targeting. J Control Release 194:341-9
, 2014. Nω-NITRO-Nω'-SUBSTITUTED GUANIDINES: A SIMPLE CLASS OF NITRIC OXIDE SYNTHASE INHIBITORS. Mod Res Inflamm 3(2):48-58
, 2013. Distinct responses of lung and liver macrophages to acute endotoxemia: role of toll-like receptor 4. Exp Mol Pathol 94(1):216-27
, 2013. Classical and alternative activation of rat hepatic sinusoidal endothelial cells by inflammatory stimuli. Exp Mol Pathol 94(1):160-7
, 2013. Toxicodynamics of rigid polystyrene microparticles on pulmonary gas exchange in mice: implications for microemboli-based drug delivery systems. Toxicol Appl Pharmacol 266(2):214-23
, 2013. Sulfur mustard induces an endoplasmic reticulum stress response in the mouse ear vesicant model. Toxicol Appl Pharmacol 268(2):178-87
, 2013. Ozone-induced injury and oxidative stress in bronchiolar epithelium are associated with altered pulmonary mechanics. Toxicol Sci 133(2):309-19
, 2013. Optimization of cell receptor-specific targeting through multivalent surface decoration of polymeric nanocarriers. J Control Release 168(1):41-9
, 2013. Sepiapterin reductase mediates chemical redox cycling in lung epithelial cells. J Biol Chem 288(26):19221-37
, 2013. The generation of 4-hydroxynonenal, an electrophilic lipid peroxidation end product, in rabbit cornea organ cultures treated with UVB light and nitrogen mustard. Toxicol Appl Pharmacol 272(2):345-55
, 2013. Age-related increases in ozone-induced injury and altered pulmonary mechanics in mice with progressive lung inflammation. Am J Physiol Lung Cell Mol Physiol 305(8):L555-68
, 2013. Coordinated role of voltage-gated sodium channels and the Na+/H+ exchanger in sustaining microglial activation during inflammation. Toxicol Appl Pharmacol 273(2):355-64
, 2012. Investigation of anticholinergic and non-steroidal anti-inflammatory prodrugs which reduce chemically induced skin inflammation. J Appl Toxicol 32(2):135-41
, 2012. Percutaneous absorption of haloacetonitriles and chloral hydrate and simulated human exposures. J Appl Toxicol 32(6):387-94
, 2012. DEP induction of ROS in capillary-like endothelial tubes leads to VEGF-A expression. Toxicology 297(1-3):34-46
, 2012. Ozone-induced lung injury and sterile inflammation. Role of toll-like receptor 4. Exp Mol Pathol 92(2):229-35
, 2012. Intestinal mucosal triacylglycerol accumulation secondary to decreased lipid secretion in obese and high fat fed mice. Front Physiol 3:25
, 2012. Role of reactive nitrogen species generated via inducible nitric oxide synthase in vesicant-induced lung injury, inflammation and altered lung functioning. Toxicol Appl Pharmacol 261(1):22-30
, 2012. Role of galectin-3 in acetaminophen-induced hepatotoxicity and inflammatory mediator production. Toxicol Sci 127(2):609-19
, 2012. Role of galectin-3 in classical and alternative macrophage activation in the liver following acetaminophen intoxication. J Immunol 189(12):5934-41
, 2012. Effects of temperature, surfactants and skin location on the dermal penetration of haloacetonitriles and chloral hydrate. J Expo Sci Environ Epidemiol 22(4):393-7
, 2012. Back-scattering interferometry: an ultrasensitive method for the unperturbed detection of acetylcholinesterase-inhibitor interactions. Angew Chem Int Ed Engl 51(44):11126-30
, 2012. Biodistribution and renal clearance of biocompatible lung targeted poly(ethylene glycol) (PEG) nanogel aggregates. J Control Release 164(1):65-73
, 2012. Regulation of alternative macrophage activation in the liver following acetaminophen intoxication by stem cell-derived tyrosine kinase. Toxicol Appl Pharmacol 262(2):139-48
, 2012. Attenuation of acute nitrogen mustard-induced lung injury, inflammation and fibrogenesis by a nitric oxide synthase inhibitor. Toxicol Appl Pharmacol 265(3):279-91
, 2012. Prolonged injury and altered lung function after ozone inhalation in mice with chronic lung inflammation. Am J Respir Cell Mol Biol 47(6):776-83
, 2012. Classical and alternative macrophage activation in the lung following ozone-induced oxidative stress. Toxicol Appl Pharmacol 263(2):195-202
, 2011. Doxycycline hydrogels with reversible disulfide crosslinks for dermal wound healing of mustard injuries. Biomaterials 32(4):1204-17
, 2011. Sulfur mustard-induced pulmonary injury: therapeutic approaches to mitigating toxicity. Pulm Pharmacol Ther 24(1):92-9
, 2011. Functional and inflammatory alterations in the lung following exposure of rats to nitrogen mustard. Toxicol Appl Pharmacol 250(1):10-8
, 2011. Structural changes in the skin of hairless mice following exposure to sulfur mustard correlate with inflammation and DNA damage. Exp Mol Pathol 91(2):515-27
, 2011. Diesel exhaust particle exposure causes redistribution of endothelial tube VE-cadherin. Toxicology 279(1-3):73-84
, 2011. Macrophages and tissue injury: agents of defense or destruction? Annu Rev Pharmacol Toxicol 51:267-88
, 2011. Role of TNFR1 in lung injury and altered lung function induced by the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide. Toxicol Appl Pharmacol 250(3):245-55
, 2011. UVB light regulates expression of antioxidants and inflammatory mediators in human corneal epithelial cells. Biochem Pharmacol 81(7):873-80
, 2011. Regulation of Hsp27 and Hsp70 expression in human and mouse skin construct models by caveolae following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide. Toxicol Appl Pharmacol 253(2):112-20
, 2011. Macrophage activation by factors released from acetaminophen-injured hepatocytes: potential role of HMGB1. Toxicol Appl Pharmacol 253(3):170-7
, 2011. Catechol metabolites of endogenous estrogens induce redox cycling and generate reactive oxygen species in breast epithelial cells. Carcinogenesis 32(8):1285-93
, 2011. Redox cycling and increased oxygen utilization contribute to diquat-induced oxidative stress and cytotoxicity in Chinese hamster ovary cells overexpressing NADPH-cytochrome P450 reductase. Free Radic Biol Med 50(7):874-82
, 2010. Threshold size for optimal passive pulmonary targeting and retention of rigid microparticles in rats. J Control Release 143(1):31-7
, 2010. Selective targeting of selenocysteine in thioredoxin reductase by the half mustard 2-chloroethyl ethyl sulfide in lung epithelial cells. Chem Res Toxicol 23(6):1045-53
, 2010. Application of the Amplex red/horseradish peroxidase assay to measure hydrogen peroxide generation by recombinant microsomal enzymes. Free Radic Biol Med 48(11):1485-91
, 2010. Potential role of caveolin-1 in acetaminophen-induced hepatotoxicity. Toxicol Appl Pharmacol 245(1):36-46
, 2010. A series of alpha-amino acid ester prodrugs of camptothecin: in vitro hydrolysis and A549 human lung carcinoma cell cytotoxicity. J Med Chem 53(3):1038-47
, 2010. Doxycycline loaded poly(ethylene glycol) hydrogels for healing vesicant-induced ocular wounds. Biomaterials 31(5):964-74
, 2010. Pulmonary targeting microparticulate camptothecin delivery system: anticancer evaluation in a rat orthotopic lung cancer model. Anticancer Drugs 21(1):65-76
, 2010. Surface modifications of nanocarriers for effective intracellular delivery of anti-HIV drugs. Adv Drug Deliv Rev 62(4-5):518-31
, 2010. Mechanisms mediating the vesicant actions of sulfur mustard after cutaneous exposure. Toxicol Sci 114(1):5-19
, 2010. Collagens. Cell Tissue Res 339(1):247-57
, 2010. Peripheral site acetylcholinesterase inhibitors targeting both inflammation and cholinergic dysfunction. Bioorg Med Chem Lett 20(9):2987-90
, 2010. Catalytic therapy of cancer with ascorbate and extracts of medicinal herbs. Evid Based Complement Alternat Med 7(2):203-12
, 2010. Janus kinase-3 dependent inflammatory responses in allergic asthma. Int Immunopharmacol 10(8):829-36
, 2010. Role of MAP kinases in regulating expression of antioxidants and inflammatory mediators in mouse keratinocytes following exposure to the half mustard, 2-chloroethyl ethyl sulfide. Toxicol Appl Pharmacol 245(3):352-60
, 2010. Inflammatory effects of phthalates in neonatal neutrophils. Pediatr Res 68(2):134-9
, 2010. Distinct roles of cytochrome P450 reductase in mitomycin C redox cycling and cytotoxicity. Mol Cancer Ther 9(6):1852-63
, 2010. Biodegradable poly(ethylene glycol) hydrogels based on a self-elimination degradation mechanism. Biomaterials 31(26):6675-84
, 2010. Inhibition of NADPH cytochrome P450 reductase by the model sulfur mustard vesicant 2-chloroethyl ethyl sulfide is associated with increased production of reactive oxygen species. Toxicol Appl Pharmacol 247(2):76-82
, 2010. Inflammatory effects of inhaled sulfur mustard in rat lung. Toxicol Appl Pharmacol 248(2):89-99
, 2010. Macrophages, reactive nitrogen species, and lung injury. Ann N Y Acad Sci 1203:60-5
, 2010. Oxidants and antioxidants in sulfur mustard-induced injury. Ann N Y Acad Sci 1203:92-100
, 2010. Mechanisms of oxidant generation by catalase. Ann N Y Acad Sci 1203:120-5
, 2010. Expression of proliferative and inflammatory markers in a full-thickness human skin equivalent following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide. Toxicol Appl Pharmacol 249(2):178-87
, 2010. Enhanced passive pulmonary targeting and retention of PEGylated rigid microparticles in rats. Int J Pharm 402(1-2):64-71
, 2010. Doxycycline hydrogels as a potential therapy for ocular vesicant injury. J Ocul Pharmacol Ther 26(5):407-19
, 2009. Differential gene expression profiling of mouse skin after sulfur mustard exposure: Extended time response and inhibitor effect. Toxicol Appl Pharmacol 234(2):156-65
, 2009. Design and evaluation of novel fast forming pilocarpine-loaded ocular hydrogels for sustained pharmacological response. J Control Release 137(2):152-9
, 2009. Nonenzymatic, self-elimination degradation mechanism of glutathione. Chem Biodivers 6(4):527-39
, 2009. Upregulation of gamma-2 laminin-332 in the mouse ear vesicant wound model. J Biochem Mol Toxicol 23(3):172-84
, 2009. Macrophages and inflammatory mediators in chemical toxicity: a battle of forces. Chem Res Toxicol 22(8):1376-85
, 2009. Pulmonary effects of inhaled diesel exhaust in aged mice. Toxicol Appl Pharmacol 241(3):283-93
, 2008. Embryonic chick corneal epithelium: a model system for exploring cell-matrix interactions. Dev Dyn 237(10):2667-75
, 2008. Increased oxidative stress and antioxidant expression in mouse keratinocytes following exposure to paraquat. Toxicol Appl Pharmacol 231(3):384-92
, 2008. UVB light upregulates prostaglandin synthases and prostaglandin receptors in mouse keratinocytes. Toxicol Appl Pharmacol 232(1):14-24
, 2008. Mechanisms mediating reduced responsiveness of neonatal neutrophils to lipoxin A4. Pediatr Res 64(4):393-8
, 2008. Regulation of TREM expression in hepatic macrophages and endothelial cells during acute endotoxemia. Exp Mol Pathol 84(2):145-55
, 2008. Regulation of caveolin-1 expression, nitric oxide production and tissue injury by tumor necrosis factor-alpha following ozone inhalation. Toxicol Appl Pharmacol 227(3):380-9
, 2008. Role of cytochrome P450 reductase in nitrofurantoin-induced redox cycling and cytotoxicity. Free Radic Biol Med 44(6):1169-79
, 2008. Distinct effects of ultraviolet B light on antioxidant expression in undifferentiated and differentiated mouse keratinocytes. Carcinogenesis 29(1):219-25
, 2007. Role of TLR-4 in liver macrophage and endothelial cell responsiveness during acute endotoxemia. Exp Mol Pathol 83(3):311-26
, 2007. Acute endotoxemia is associated with upregulation of lipocalin 24p3/Lcn2 in lung and liver. Exp Mol Pathol 83(2):177-87
, 2007. Paraquat increases cyanide-insensitive respiration in murine lung epithelial cells by activating an NAD(P)H:paraquat oxidoreductase: identification of the enzyme as thioredoxin reductase. J Biol Chem 282(11):7939-49
Publication list retrieved from NCBI using ImpactPubs
.