Debra L. Laskin, Ph.D.

Vesicant-induced Pulmonary Injury
Distinguished Professor & Chair, Pharmacology & Toxicology, Ernest Mario School of Pharmacy, Rutgers University

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Recent Publications

Radbel, J, Meshanni, JA, Vayas, KN, Le-Hoang, O, Abramova, E, Zhou, P, Joseph, LB, Laskin, JD, Gow, AJ, Laskin, DL. Effects of ozone exposure on lung injury, inflammation, and oxidative stress in a murine model of non-pneumonic endotoxemia. Toxicol Sci. 2024; :. PubMed PMID:38749002 .

Bellomo, A, Herbert, J, Kudlak, MJ, Laskin, JD, Gow, AJ, Laskin, DL. Identification of early events in nitrogen mustard pulmonary toxicity that are independent of infiltrating inflammatory cells using precision cut lung slices. Toxicol Appl Pharmacol. 2024;486 :116941. PubMed PMID:38677601 .

Malaviya, R, Meshanni, JA, Sunil, VR, Venosa, A, Guo, C, Abramova, EV, Vayas, KN, Jiang, C, Cervelli, JA, Gow, AJ, Laskin, JD, Laskin, DL. Role of macrophage bioenergetics in N-acetylcysteine-mediated mitigation of lung injury and oxidative stress induced by nitrogen mustard. Toxicol Appl Pharmacol. 2024;485 :116908. PubMed PMID:38513841 .

Gutierrez, B, Aggarwal, T, Erguven, H, Stone, MRL, Guo, C, Bellomo, A, Abramova, E, Stevenson, ER, Laskin, DL, Gow, AJ, Izgu, EC. Direct assessment of nitrative stress in lipid environments: Applications of a designer lipid-based biosensor for peroxynitrite. iScience. 2023;26 (12):108567. PubMed PMID:38144454 PubMed Central PMC10746523.

Laskin, JD, Ozkuyumcu, K, Zhou, P, Croutch, CR, Heck, DE, Laskin, DL, Joseph, LB. Skin Models Used to Define Mechanisms of Action of Sulfur Mustard. Disaster Med Public Health Prep. 2023;17 :e551. PubMed PMID:37849329 .

Malaviya, R, Laskin, JD, Businaro, R, Laskin, DL. Targeting Tumor Necrosis Factor Alpha to Mitigate Lung Injury Induced by Mustard Vesicants and Radiation. Disaster Med Public Health Prep. 2023;17 :e553. PubMed PMID:37848400 PubMed Central PMC10841250.

Smith, LC, Gow, AJ, Abramova, E, Vayas, K, Guo, C, Noto, J, Lyman, J, Rodriquez, J, Gelfand-Titiyevskiy, B, Malcolm, C, Laskin, JD, Laskin, DL. Role of PPARγ in dyslipidemia and altered pulmonary functioning in mice following ozone exposure. Toxicol Sci. 2023;194 (1):109-119. PubMed PMID:37202362 PubMed Central PMC10306402.

Meshanni, JA, Lee, JM, Vayas, KN, Sun, R, Jiang, C, Guo, GL, Gow, AJ, Laskin, JD, Laskin, DL. Suppression of Lung Oxidative Stress, Inflammation, and Fibrosis following Nitrogen Mustard Exposure by the Selective Farnesoid X Receptor Agonist Obeticholic Acid. J Pharmacol Exp Ther. 2024;388 (2):586-595. PubMed PMID:37188530 PubMed Central PMC10801770.

Cary, CM, Seymore, TN, Singh, D, Vayas, KN, Goedken, MJ, Adams, S, Polunas, M, Sunil, VR, Laskin, DL, Demokritou, P, Stapleton, PA. Single inhalation exposure to polyamide micro and nanoplastic particles impairs vascular dilation without generating pulmonary inflammation in virgin female Sprague Dawley rats. Part Fibre Toxicol. 2023;20 (1):16. PubMed PMID:37088832 PubMed Central PMC10122824.

Gowdy, KM, Laskin, DL. Resolution of inflammation in xenobiotic-induced mucosal injury and chronic disease. Toxicol Appl Pharmacol. 2023;466 :116455. PubMed PMID:36907382 .

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