Debra L. Laskin, Ph.D.

Vesicant-induced Pulmonary Injury
Distinguished Professor & Chair, Pharmacology & Toxicology, Ernest Mario School of Pharmacy, Rutgers University

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Recent Publications

Sunil, VR, Vayas, KN, Radbel, J, Abramova, E, Gow, A, Laskin, JD, Laskin, DL. Impaired energy metabolism and altered functional activity of alveolar type II epithelial cells following exposure of rats to nitrogen mustard. Toxicol Appl Pharmacol. 2022; :116257. PubMed PMID:36174670 .

Murray, A, Banota, T, Guo, GL, Smith, LC, Meshanni, JA, Lee, J, Kong, B, Abramova, EV, Goedken, M, Gow, AJ, Laskin, JD, Laskin, DL. Farnesoid X receptor regulates lung macrophage activation and injury following nitrogen mustard exposure. Toxicol Appl Pharmacol. 2022;454 :116208. PubMed PMID:35998709 .

Joseph, LB, Gordon, MK, Zhou, P, Hahn, RA, Lababidi, H, Croutch, CR, Sinko, PJ, Heck, DE, Laskin, DL, Laskin, JD. Sulfur mustard corneal injury is associated with alterations in the epithelial basement membrane and stromal extracellular matrix. Exp Mol Pathol. 2022;128 :104807. PubMed PMID:35798063 .

Jan, YH, Heck, DE, An, Y, Laskin, DL, Laskin, JD. Nitrogen Mustard Alkylates and Cross-Links p53 in Human Keratinocytes. Chem Res Toxicol. 2022;35 (4):636-650. PubMed PMID:35312310 PubMed Central PMC9491701.

Carnino, JM, Lee, H, Smith, LC, Sunil, VR, Rancourt, RC, Vayas, K, Cervelli, J, Kwok, ZH, Ni, K, Laskin, JD, Jin, Y, Laskin, DL. Microvesicle-Derived miRNAs Regulate Proinflammatory Macrophage Activation in the Lung Following Ozone Exposure. Toxicol Sci. 2022;187 (1):162-174. PubMed PMID:35201360 PubMed Central PMC9041552.

Malaviya, R, Bellomo, A, Abramova, E, Croutch, CR, Roseman, J, Tuttle, R, Peters, E, Casillas, RP, Sunil, VR, Laskin, JD, Laskin, DL. Pulmonary injury and oxidative stress in rats induced by inhaled sulfur mustard is ameliorated by anti-tumor necrosis factor-α antibody. Toxicol Appl Pharmacol. 2021;428 :115677. PubMed PMID:34390737 PubMed Central PMC8452183.

Joseph, LB, Gordon, MK, Kang, J, Croutch, CR, Zhou, P, Heck, DE, Laskin, DL, Laskin, JD. Characterization of the rabbit conjunctiva: Effects of sulfur mustard. Exp Mol Pathol. 2021;121 :104656. PubMed PMID:34081961 PubMed Central PMC9006340.

Venosa, A, Smith, LC, Gow, AJ, Zarbl, H, Laskin, JD, Laskin, DL. Macrophage activation in the lung during the progression of nitrogen mustard induced injury is associated with histone modifications and altered miRNA expression. Toxicol Appl Pharmacol. 2021;423 :115569. PubMed PMID:33971176 PubMed Central PMC8496734.

Venosa, A, Gow, JG, Taylor, S, Golden, TN, Murray, A, Abramova, E, Malaviya, R, Laskin, DL, Gow, AJ. Myeloid cell dynamics in bleomycin-induced pulmonary injury in mice; effects of anti-TNFα antibody. Toxicol Appl Pharmacol. 2021;417 :115470. PubMed PMID:33647319 .

Murray, A, Gow, AJ, Venosa, A, Andres, J, Malaviya, R, Adler, D, Yurkow, E, Laskin, JD, Laskin, DL. Assessment of mustard vesicant lung injury and anti-TNF-α efficacy in rodents using live-animal imaging. Ann N Y Acad Sci. 2020;1480 (1):246-256. PubMed PMID:33165947 PubMed Central PMC7968421.

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