Robert Casillas, Ph.D.

Director, Nonclinical Consulting, Latham BioPharm Group

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Recent Publications

Hobson, ST, Casillas, RP, Richieri, RA, Nishimura, RN, Weisbart, RH, Tuttle, R, Reynolds, GT, Parseghian, MH. Development of an acute, short-term exposure model for phosgene. Toxicol. Mech. Methods. 2019;29 (8):604-615. PubMed PMID:31237465 PubMed Central PMC6715518.

Chang, YC, Soriano, M, Hahn, RA, Casillas, RP, Gordon, MK, Laskin, JD, Gerecke, DR. Expression of cytokines and chemokines in mouse skin treated with sulfur mustard. Toxicol. Appl. Pharmacol. 2018;355 :52-59. PubMed PMID:29935281 PubMed Central PMC6438172.

Joseph, LB, Composto, GM, Perez, RM, Kim, HD, Casillas, RP, Heindel, ND, Young, SC, Lacey, CJ, Saxena, J, Guillon, CD, Croutch, CR, Laskin, JD, Heck, DE. Sulfur mustard induced mast cell degranulation in mouse skin is inhibited by a novel anti-inflammatory and anticholinergic bifunctional prodrug. Toxicol. Lett. 2018;293 :77-81. PubMed PMID:29127031 PubMed Central PMC5938161.

Tewari-Singh, N, Goswami, DG, Kant, R, Ammar, DA, Kumar, D, Enzenauer, RW, Casillas, RP, Croutch, CR, Petrash, JM, Agarwal, R. Histopathological and Molecular Changes in the Rabbit Cornea From Arsenical Vesicant Lewisite Exposure. Toxicol. Sci. 2017;160 (2):420-428. PubMed PMID:28973427 PubMed Central PMC5837587.

Tewari-Singh, N, Goswami, DG, Kant, R, Croutch, CR, Casillas, RP, Orlicky, DJ, Agarwal, R. Cutaneous exposure to vesicant phosgene oxime: Acute effects on the skin and systemic toxicity. Toxicol. Appl. Pharmacol. 2017;317 :25-32. PubMed PMID:28087322 .

Composto, GM, Laskin, JD, Laskin, DL, Gerecke, DR, Casillas, RP, Heindel, ND, Joseph, LB, Heck, DE. Mitigation of nitrogen mustard mediated skin injury by a novel indomethacin bifunctional prodrug. Exp. Mol. Pathol. 2016;100 (3):522-31. PubMed PMID:27189522 PubMed Central PMC4947376.

Wohlman, IM, Composto, GM, Heck, DE, Heindel, ND, Lacey, CJ, Guillon, CD, Casillas, RP, Croutch, CR, Gerecke, DR, Laskin, DL, Joseph, LB, Laskin, JD. Mustard vesicants alter expression of the endocannabinoid system in mouse skin. Toxicol. Appl. Pharmacol. 2016;303 :30-44. PubMed PMID:27125198 PubMed Central PMC4947375.

Tewari-Singh, N, Croutch, CR, Tuttle, R, Goswami, DG, Kant, R, Peters, E, Culley, T, Ammar, DA, Enzenauer, RW, Petrash, JM, Casillas, RP, Agarwal, R. Clinical progression of ocular injury following arsenical vesicant lewisite exposure. Cutan Ocul Toxicol. 2016;35 (4):319-28. PubMed PMID:27002633 PubMed Central PMC5082841.

Jan, YH, Heck, DE, Casillas, RP, Laskin, DL, Laskin, JD. Thioredoxin Cross-Linking by Nitrogen Mustard in Lung Epithelial Cells: Formation of Multimeric Thioredoxin/Thioredoxin Reductase Complexes and Inhibition of Disulfide Reduction. Chem. Res. Toxicol. 2015;28 (11):2091-103. PubMed PMID:26451472 PubMed Central PMC4877171.

Chang, YC, Wang, JD, Hahn, RA, Gordon, MK, Joseph, LB, Heck, DE, Heindel, ND, Young, SC, Sinko, PJ, Casillas, RP, Laskin, JD, Laskin, DL, Gerecke, DR. Therapeutic potential of a non-steroidal bifunctional anti-inflammatory and anti-cholinergic agent against skin injury induced by sulfur mustard. Toxicol. Appl. Pharmacol. 2014;280 (2):236-44. PubMed PMID:25127551 PubMed Central PMC4254337.

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