Diane Heck, Ph.D.

Pharmacology & Drug Development
Professor & Chair, Department of Environmental Health Science, School of Health Sciences and Practice, New York Medical College

[Link to Bio] [Back to Members Page]

Recent Publications

Guillon, C, Jan, YH, Heck, DE, Mariano, TM, Rapp, RD, Jetter, M, Kardos, K, Whittemore, M, Akyea, E, Jabin, I, Laskin, JD, Heindel, ND. Phototoxicity of 7-oxycoumarins with keratinocytes in culture. Bioorg. Chem. 2019;89 :103014. PubMed PMID:31170642 PubMed Central PMC6656587.

Jan, YH, Heck, DE, Laskin, DL, Laskin, JD. Sulfur Mustard Analog Mechlorethamine (Bis(2-chloroethyl)methylamine) Modulates Cell Cycle Progression via the DNA Damage Response in Human Lung Epithelial A549 Cells. Chem. Res. Toxicol. 2019;32 (6):1123-1133. PubMed PMID:30964658 PubMed Central PMC6626495.

Guillon, CD, Jan, YH, Foster, N, Ressner, J, Heck, DE, Laskin, JD, Heindel, ND. Synthetically modified methoxsalen for enhanced cytotoxicity in light and dark reactions. Bioorg. Med. Chem. Lett. 2019;29 (4):619-622. PubMed PMID:30638875 PubMed Central PMC6364570.

Szilagyi, JT, Fussell, KC, Wang, Y, Jan, YH, Mishin, V, Richardson, JR, Heck, DE, Yang, S, Aleksunes, LM, Laskin, DL, Laskin, JD. Quinone and nitrofurantoin redox cycling by recombinant cytochrome b5 reductase. Toxicol. Appl. Pharmacol. 2018;359 :102-107. PubMed PMID:30222979 PubMed Central PMC6528659.

Laskin, JD, Jan, YH, Jetter, MM, Guillon, CD, Mariano, TM, Heck, DE, Heindel, ND. Identification of a Pyranocoumarin Photosensitizer that is a Potent Inhibitor of Keratinocyte Growth. Photochem. Photobiol. 2018;94 (3):577-582. PubMed PMID:29315592 .

Joseph, LB, Composto, GM, Perez, RM, Kim, HD, Casillas, RP, Heindel, ND, Young, SC, Lacey, CJ, Saxena, J, Guillon, CD, Croutch, CR, Laskin, JD, Heck, DE. Sulfur mustard induced mast cell degranulation in mouse skin is inhibited by a novel anti-inflammatory and anticholinergic bifunctional prodrug. Toxicol. Lett. 2018;293 :77-81. PubMed PMID:29127031 PubMed Central PMC5938161.

Yang, S, Jan, YH, Mishin, V, Heck, DE, Laskin, DL, Laskin, JD. Diacetyl/l-Xylulose Reductase Mediates Chemical Redox Cycling in Lung Epithelial Cells. Chem. Res. Toxicol. 2017;30 (7):1406-1418. PubMed PMID:28595002 PubMed Central PMC5708134.

Lacey, CJ, Wohlman, I, Guillon, C, Saxena, J, Fianu-Velgus, C, Aponte, E, Young, SC, Heck, DE, Joseph, LB, Laskin, JD, Heindel, ND. Multi-inhibitor prodrug constructs for simultaneous delivery of anti-inflammatory agents to mustard-induced skin injury. Ann. N. Y. Acad. Sci. 2016;1378 (1):174-179. PubMed PMID:27505078 PubMed Central PMC5063683.

Jan, YH, Richardson, JR, Baker, AA, Mishin, V, Heck, DE, Laskin, DL, Laskin, JD. Novel approaches to mitigating parathion toxicity: targeting cytochrome P450-mediated metabolism with menadione. Ann. N. Y. Acad. Sci. 2016;1378 (1):80-86. PubMed PMID:27441453 PubMed Central PMC5220671.

Shakarjian, MP, Laukova, M, Velíšková, J, Stanton, PK, Heck, DE, Velíšek, L. Tetramethylenedisulfotetramine: pest control gone awry. Ann. N. Y. Acad. Sci. 2016;1378 (1):68-79. PubMed PMID:27384716 PubMed Central PMC5063667.

More Publications