Laurie B. Joseph, Ph.D.
Investigator
Associate Research Professor, Pharmacology & Toxicology, Ernest Mario School of Pharmacy, Rutgers University
Recent Publications
Basaly, V, Henry, ZR, Taylor, RE, Kong, B, Yang, I, Brinker, A, Yang, Z, Zhou, P, Joseph, LB, Aleksunes, L, Buckley, B, Negishi, M, Guo, GL. Mutation of PXR phosphorylation motif at Ser347 disrupts lipid and bile acid homeostasis in diet-induced metabolic dysfunction-associated steatohepatitis in mice. Drug Metab Dispos. 2025;54 (2):100222. PubMed PMID:41520575 .
Henry, ZR, Maliha, S, Basaly, V, Yang, Z, Taylor, RE, Otersen, K, Meadows, V, Rizzolo, D, Stofan, M, Bhattacharya, A, Zhou, P, Brinker, A, Yang, I, Zhang, L, Joseph, LB, Buckley, B, Kong, B, Guo, GL. Ursodeoxycholic acid acts as an ileal FXR agonist in male mice with hepatic deficiency of FXR. eGastroenterology. 2025;3 (3):e100227. PubMed PMID:41036243 PubMed Central PMC12481312.
Henry, ZR, Armstrong, L, Maliha, S, Jia, X, Gao, S, Taylor, RE, Basaly, V, Otersen, K, Yang, Z, Rizzolo, D, Stofan, M, Meadows, V, Bhattacharya, A, Zhou, P, Yang, I, Brinker, A, Zhou, L, Zhu, H, Joseph, LB, Buckley, B, Anthony, T, Aleksunes, L, Kong, B, Guo, GL. Deletion of hepatic FXR leads to more severe MASH development in female mice. Hepatol Commun. 2025;9 (6):. PubMed PMID:40377496 PubMed Central PMC12088634.
Taylor, R, Basaly, V, Kong, B, Yang, I, Brinker, AM, Capece, G, Bhattacharya, A, Henry, ZR, Otersen, K, Yang, Z, Meadows, V, Mera, S, Joseph, LB, Zhou, P, Aleksunes, LM, Roepke, T, Buckley, B, Guo, GL. Effects of therapeutically approved individual bile acids on the development of metabolic dysfunction-associated steatohepatitis a low bile acid mouse model. Toxicol Sci. 2024;202 (2):179-195. PubMed PMID:39302723 PubMed Central PMC12104526.
Radbel, J, Meshanni, JA, Vayas, KN, Le-Hoang, O, Abramova, E, Zhou, P, Joseph, LB, Laskin, JD, Gow, AJ, Laskin, DL. Effects of ozone exposure on lung injury, inflammation, and oxidative stress in a murine model of nonpneumonic endotoxemia. Toxicol Sci. 2024;200 (2):299-311. PubMed PMID:38749002 PubMed Central PMC11285192.
Taylor, R, Yang, Z, Henry, Z, Capece, G, Meadows, V, Otersen, K, Basaly, V, Bhattacharya, A, Mera, S, Zhou, P, Joseph, L, Yang, I, Brinker, A, Buckley, B, Kong, B, Guo, GL. Characterization of individual bile acids in vivo utilizing a novel low bile acid mouse model. Toxicol Sci. 2024;199 (2):316-331. PubMed PMID:38526215 PubMed Central PMC12104498.
Laskin, JD, Ozkuyumcu, K, Zhou, P, Croutch, CR, Heck, DE, Laskin, DL, Joseph, LB. Skin Models Used to Define Mechanisms of Action of Sulfur Mustard. Disaster Med Public Health Prep. 2023;17 :e551. PubMed PMID:37849329 PubMed Central PMC11420828.
Joseph, LB, Gordon, MK, Zhou, P, Hahn, RA, Lababidi, H, Croutch, CR, Sinko, PJ, Heck, DE, Laskin, DL, Laskin, JD. Sulfur mustard corneal injury is associated with alterations in the epithelial basement membrane and stromal extracellular matrix. Exp Mol Pathol. 2022;128 :104807. PubMed PMID:35798063 PubMed Central PMC10044521.
Joseph, LB, Gordon, MK, Kang, J, Croutch, CR, Zhou, P, Heck, DE, Laskin, DL, Laskin, JD. Characterization of the rabbit conjunctiva: Effects of sulfur mustard. Exp Mol Pathol. 2021;121 :104656. PubMed PMID:34081961 PubMed Central PMC9006340.
Honarbakhsh, M, Ericsson, A, Zhong, G, Isoherranen, N, Zhu, C, Bromberg, Y, Van Buiten, C, Malta, K, Joseph, L, Sampath, H, Lackey, AI, Storch, J, Vetriani, C, Chikindas, ML, Breslin, P, Quadro, L. Impact of vitamin A transport and storage on intestinal retinoid homeostasis and functions. J Lipid Res. 2021;62 :100046. PubMed PMID:33587919 PubMed Central PMC8020483.
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