Lauren Aleksunes, Pharm.D., Ph.D.

Investigator
Professor, Pharmacology & Toxicology, Ernest Mario School of Pharmacy, Rutgers University

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Recent Publications

Scialis, RJ, Aleksunes, LM, Csanaky, IL, Klaassen, CD, Manautou, JE. Identification and Characterization of Efflux Transporters That Modulate the Subtoxic Disposition of Diclofenac and Its Metabolites. Drug Metab. Dispos. 2019;47 (10):1080-1092. PubMed PMID:31399506 PubMed Central PMC6750190.

You, D, Wen, X, Gorczyca, L, Morris, A, Richardson, JR, Aleksunes, LM. Increased MDR1 Transporter Expression in Human Brain Endothelial Cells Through Enhanced Histone Acetylation and Activation of Aryl Hydrocarbon Receptor Signaling. Mol. Neurobiol. 2019;56 (10):6986-7002. PubMed PMID:30963442 PubMed Central PMC6728213.

Russo, DP, Strickland, J, Karmaus, AL, Wang, W, Shende, S, Hartung, T, Aleksunes, LM, Zhu, H. Nonanimal Models for Acute Toxicity Evaluations: Applying Data-Driven Profiling and Read-Across. Environ. Health Perspect. 2019;127 (4):47001. PubMed PMID:30933541 PubMed Central PMC6785238.

You, D, Shin, HM, Mosaad, F, Richardson, JR, Aleksunes, LM. Brain region-specific regulation of histone acetylation and efflux transporters in mice. J. Biochem. Mol. Toxicol. 2019; :e22318. PubMed PMID:30897286 PubMed Central PMC6754812.

Wen, X, Baker, AA, Klaassen, CD, Corton, JC, Richardson, JR, Aleksunes, LM. Hepatic carboxylesterases are differentially regulated in PPARα-null mice treated with perfluorooctanoic acid. Toxicology. 2019;416 :15-22. PubMed PMID:30685356 PubMed Central PMC6397673.

Szilagyi, JT, Composto-Wahler, GM, Joseph, LB, Wang, B, Rosen, T, Laskin, JD, Aleksunes, LM. Anandamide down-regulates placental transporter expression through CB2 receptor-mediated inhibition of cAMP synthesis. Pharmacol. Res. 2019;141 :331-342. PubMed PMID:30610963 PubMed Central PMC6391190.

Szilagyi, JT, Gorczyca, L, Brinker, A, Buckley, B, Laskin, JD, Aleksunes, LM. Placental BCRP/ABCG2 Transporter Prevents Fetal Exposure to the Estrogenic Mycotoxin Zearalenone. Toxicol. Sci. 2019;168 (2):394-404. PubMed PMID:30576553 PubMed Central PMC6432861.

Szilagyi, JT, Fussell, KC, Wang, Y, Jan, YH, Mishin, V, Richardson, JR, Heck, DE, Yang, S, Aleksunes, LM, Laskin, DL, Laskin, JD. Quinone and nitrofurantoin redox cycling by recombinant cytochrome b5 reductase. Toxicol. Appl. Pharmacol. 2018;359 :102-107. PubMed PMID:30222979 PubMed Central PMC6528659.

Ibrahim, ME, Chang, C, Hu, Y, Hogan, SL, Mercke, N, Gomez, M, O'Bryant, CL, Bowles, DW, George, B, Wen, X, Buckley, B, Aleksunes, L, Joy, MS. Pharmacokinetic determinants of cisplatin-induced subclinical kidney injury in oncology patients. Eur. J. Clin. Pharmacol. 2019;75 (1):51-57. PubMed PMID:30220072 PubMed Central PMC6656531.

Memon, N, Griffin, IJ, Lee, CW, Herdt, A, Weinberger, BI, Hegyi, T, Carayannopoulos, MO, Aleksunes, LM, Guo, GL. Developmental regulation of the gut-liver (FGF19-CYP7A1) axis in neonates. J. Matern. Fetal. Neonatal. Med. 2020;33 (6):987-992. PubMed PMID:30122083 PubMed Central PMC6488437.

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