Ned Heindel, Ph.D.

Medicinal Chemistry
Howard S. Bunn Distinguished Professor of Chemistry, Lehigh University

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Recent Publications

Guillon, C, Vetrano, AM, Saxena, J, Hunter, A, Verderone, G, Finetti, TM, Wisnoski, J, DeMatteo, PW, Rapp, RD, Heindel, ND, Joseph, LB, Heck, DE, Laskin, JD. Derivatives of 1,2,4-triazole imines acting as dual iNOS and tumor cell growth inhibitors. Bioorg Chem. 2020;103 :104128. PubMed PMID:32745761 PubMed Central PMC7819682.

Wahler, G, Heck, DE, Heindel, ND, Laskin, DL, Laskin, JD, Joseph, LB. Antioxidant/stress response in mouse epidermis following exposure to nitrogen mustard. Exp Mol Pathol. 2020;114 :104410. PubMed PMID:32113906 PubMed Central PMC7237310.

Guillon, C, Jan, YH, Heck, DE, Mariano, TM, Rapp, RD, Jetter, M, Kardos, K, Whittemore, M, Akyea, E, Jabin, I, Laskin, JD, Heindel, ND. Phototoxicity of 7-oxycoumarins with keratinocytes in culture. Bioorg Chem. 2019;89 :103014. PubMed PMID:31170642 PubMed Central PMC6656587.

Guillon, CD, Jan, YH, Foster, N, Ressner, J, Heck, DE, Laskin, JD, Heindel, ND. Synthetically modified methoxsalen for enhanced cytotoxicity in light and dark reactions. Bioorg Med Chem Lett. 2019;29 (4):619-622. PubMed PMID:30638875 PubMed Central PMC6364570.

Guillon, CD, Jan, YH, Foster, N, Choudhuri, M, Saxena, J, Mariano, TM, Heck, DE, Laskin, JD, Heindel, ND. SYNTHESIS AND EVALUATION OF WATER-SOLUBLE DIMETHYLAMINOETHYL ETHERS OF METHOXSALEN FOR PROLIFERATIVE SKIN DISORDERS. Heterocycl Lett. 2018;8 (4):729-736. PubMed PMID:33575202 PubMed Central PMC7875182.

Laskin, JD, Jan, YH, Jetter, MM, Guillon, CD, Mariano, TM, Heck, DE, Heindel, ND. Identification of a Pyranocoumarin Photosensitizer that is a Potent Inhibitor of Keratinocyte Growth. Photochem Photobiol. 2018;94 (3):577-582. PubMed PMID:29315592 .

Joseph, LB, Composto, GM, Perez, RM, Kim, HD, Casillas, RP, Heindel, ND, Young, SC, Lacey, CJ, Saxena, J, Guillon, CD, Croutch, CR, Laskin, JD, Heck, DE. Sulfur mustard induced mast cell degranulation in mouse skin is inhibited by a novel anti-inflammatory and anticholinergic bifunctional prodrug. Toxicol Lett. 2018;293 :77-81. PubMed PMID:29127031 PubMed Central PMC5938161.

Lacey, CJ, Wohlman, I, Guillon, C, Saxena, J, Fianu-Velgus, C, Aponte, E, Young, SC, Heck, DE, Joseph, LB, Laskin, JD, Heindel, ND. Multi-inhibitor prodrug constructs for simultaneous delivery of anti-inflammatory agents to mustard-induced skin injury. Ann N Y Acad Sci. 2016;1378 (1):174-179. PubMed PMID:27505078 PubMed Central PMC5063683.

Composto, GM, Laskin, JD, Laskin, DL, Gerecke, DR, Casillas, RP, Heindel, ND, Joseph, LB, Heck, DE. Mitigation of nitrogen mustard mediated skin injury by a novel indomethacin bifunctional prodrug. Exp Mol Pathol. 2016;100 (3):522-31. PubMed PMID:27189522 PubMed Central PMC4947376.

Wohlman, IM, Composto, GM, Heck, DE, Heindel, ND, Lacey, CJ, Guillon, CD, Casillas, RP, Croutch, CR, Gerecke, DR, Laskin, DL, Joseph, LB, Laskin, JD. Mustard vesicants alter expression of the endocannabinoid system in mouse skin. Toxicol Appl Pharmacol. 2016;303 :30-44. PubMed PMID:27125198 PubMed Central PMC4947375.

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