Ned Heindel, Ph.D.

Medicinal Chemistry
Howard S. Bunn Distinguished Professor of Chemistry, Lehigh University

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Recent Publications

Guillon, C, Jan, YH, Heck, DE, Mariano, TM, Rapp, RD, Jetter, M, Kardos, K, Whittemore, M, Akyea, E, Jabin, I, Laskin, JD, Heindel, ND. Phototoxicity of 7-oxycoumarins with keratinocytes in culture. Bioorg. Chem. 2019;89 :103014. PubMed PMID:31170642 PubMed Central PMC6656587.

Guillon, CD, Jan, YH, Foster, N, Ressner, J, Heck, DE, Laskin, JD, Heindel, ND. Synthetically modified methoxsalen for enhanced cytotoxicity in light and dark reactions. Bioorg. Med. Chem. Lett. 2019;29 (4):619-622. PubMed PMID:30638875 PubMed Central PMC6364570.

Laskin, JD, Jan, YH, Jetter, MM, Guillon, CD, Mariano, TM, Heck, DE, Heindel, ND. Identification of a Pyranocoumarin Photosensitizer that is a Potent Inhibitor of Keratinocyte Growth. Photochem. Photobiol. 2018;94 (3):577-582. PubMed PMID:29315592 .

Joseph, LB, Composto, GM, Perez, RM, Kim, HD, Casillas, RP, Heindel, ND, Young, SC, Lacey, CJ, Saxena, J, Guillon, CD, Croutch, CR, Laskin, JD, Heck, DE. Sulfur mustard induced mast cell degranulation in mouse skin is inhibited by a novel anti-inflammatory and anticholinergic bifunctional prodrug. Toxicol. Lett. 2018;293 :77-81. PubMed PMID:29127031 PubMed Central PMC5938161.

Lacey, CJ, Wohlman, I, Guillon, C, Saxena, J, Fianu-Velgus, C, Aponte, E, Young, SC, Heck, DE, Joseph, LB, Laskin, JD, Heindel, ND. Multi-inhibitor prodrug constructs for simultaneous delivery of anti-inflammatory agents to mustard-induced skin injury. Ann. N. Y. Acad. Sci. 2016;1378 (1):174-179. PubMed PMID:27505078 PubMed Central PMC5063683.

Composto, GM, Laskin, JD, Laskin, DL, Gerecke, DR, Casillas, RP, Heindel, ND, Joseph, LB, Heck, DE. Mitigation of nitrogen mustard mediated skin injury by a novel indomethacin bifunctional prodrug. Exp. Mol. Pathol. 2016;100 (3):522-31. PubMed PMID:27189522 PubMed Central PMC4947376.

Wohlman, IM, Composto, GM, Heck, DE, Heindel, ND, Lacey, CJ, Guillon, CD, Casillas, RP, Croutch, CR, Gerecke, DR, Laskin, DL, Joseph, LB, Laskin, JD. Mustard vesicants alter expression of the endocannabinoid system in mouse skin. Toxicol. Appl. Pharmacol. 2016;303 :30-44. PubMed PMID:27125198 PubMed Central PMC4947375.

DeSantis-Rodrigues, A, Chang, YC, Hahn, RA, Po, IP, Zhou, P, Lacey, CJ, Pillai, A, C Young, S, Flowers, RA 2nd, Gallo, MA, Laskin, JD, Gerecke, DR, Svoboda, KK, Heindel, ND, Gordon, MK. ADAM17 Inhibitors Attenuate Corneal Epithelial Detachment Induced by Mustard Exposure. Invest. Ophthalmol. Vis. Sci. 2016;57 (4):1687-98. PubMed PMID:27058125 PubMed Central PMC4829087.

Szilagyi, JT, Mishin, V, Heck, DE, Jan, YH, Aleksunes, LM, Richardson, JR, Heindel, ND, Laskin, DL, Laskin, JD. Selective Targeting of Heme Protein in Cytochrome P450 and Nitric Oxide Synthase by Diphenyleneiodonium. Toxicol. Sci. 2016;151 (1):150-9. PubMed PMID:26880746 PubMed Central PMC4914801.

Saxena, J, Meloni, D, Huang, MT, Heck, DE, Laskin, JD, Heindel, ND, Young, SC. Ethynylphenyl carbonates and carbamates as dual-action acetylcholinesterase inhibitors and anti-inflammatory agents. Bioorg. Med. Chem. Lett. 2015;25 (23):5609-12. PubMed PMID:26510670 PubMed Central PMC4700827.

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