Laurie B. Joseph, Ph.D.
Investigator
Associate Research Professor, Pharmacology & Toxicology, Ernest Mario School of Pharmacy, Rutgers University
Recent Publications
Cary, CM, Gadsden, NN, Zhou, P, Joseph, LB, Nguyen, C, Polunas, M, Goedken, MJ, Aleksunes, LM, Stapleton, PA. Micro and nanoplastic inhalation during gestation disrupts placentation in the Sprague-Dawley rat. Res Sq. 2026; :. PubMed PMID:42370262 PubMed Central PMC13308420.
Seymore, T, McWilliams, D, Ozkuyumcu, K, Louro, P, Cary, C, Goedken, M, Joseph, L, Stapleton, P. Gestational inhalation of nanoparticles disrupts placental zone structure and induces vascular placentation in rats. bioRxiv. 2026; :. PubMed PMID:42327074 PubMed Central PMC13277972.
Jan, YH, Michniak-Kohn, B, Joseph, LB, Laskin, DL, Laskin, JD. Nitrogen Mustard Disrupts Bioenergetics and Activates Oxidative Stress-Induced Cell Death Pathways in Human Keratinocytes. Chem Res Toxicol. 2026;39 (6):1178-1189. PubMed PMID:42205054 PubMed Central PMC13273801.
Basaly, V, Henry, ZR, Taylor, RE, Kong, B, Yang, I, Brinker, A, Yang, Z, Zhou, P, Joseph, LB, Aleksunes, L, Buckley, B, Negishi, M, Guo, GL. Mutation of PXR phosphorylation motif at Ser347 disrupts lipid and bile acid homeostasis in diet-induced metabolic dysfunction-associated steatohepatitis in mice. Drug Metab Dispos. 2026;54 (2):100222. PubMed PMID:41520575 PubMed Central PMC12975368.
Henry, ZR, Maliha, S, Basaly, V, Yang, Z, Taylor, RE, Otersen, K, Meadows, V, Rizzolo, D, Stofan, M, Bhattacharya, A, Zhou, P, Brinker, A, Yang, I, Zhang, L, Joseph, LB, Buckley, B, Kong, B, Guo, GL. Ursodeoxycholic acid acts as an ileal FXR agonist in male mice with hepatic deficiency of FXR. eGastroenterology. 2025;3 (3):e100227. PubMed PMID:41036243 PubMed Central PMC12481312.
Henry, ZR, Armstrong, L, Maliha, S, Jia, X, Gao, S, Taylor, RE, Basaly, V, Otersen, K, Yang, Z, Rizzolo, D, Stofan, M, Meadows, V, Bhattacharya, A, Zhou, P, Yang, I, Brinker, A, Zhou, L, Zhu, H, Joseph, LB, Buckley, B, Anthony, T, Aleksunes, L, Kong, B, Guo, GL. Deletion of hepatic FXR leads to more severe MASH development in female mice. Hepatol Commun. 2025;9 (6):. PubMed PMID:40377496 PubMed Central PMC12088634.
Taylor, R, Basaly, V, Kong, B, Yang, I, Brinker, AM, Capece, G, Bhattacharya, A, Henry, ZR, Otersen, K, Yang, Z, Meadows, V, Mera, S, Joseph, LB, Zhou, P, Aleksunes, LM, Roepke, T, Buckley, B, Guo, GL. Effects of therapeutically approved individual bile acids on the development of metabolic dysfunction-associated steatohepatitis a low bile acid mouse model. Toxicol Sci. 2024;202 (2):179-195. PubMed PMID:39302723 PubMed Central PMC12104526.
Radbel, J, Meshanni, JA, Vayas, KN, Le-Hoang, O, Abramova, E, Zhou, P, Joseph, LB, Laskin, JD, Gow, AJ, Laskin, DL. Effects of ozone exposure on lung injury, inflammation, and oxidative stress in a murine model of nonpneumonic endotoxemia. Toxicol Sci. 2024;200 (2):299-311. PubMed PMID:38749002 PubMed Central PMC11285192.
Taylor, R, Yang, Z, Henry, Z, Capece, G, Meadows, V, Otersen, K, Basaly, V, Bhattacharya, A, Mera, S, Zhou, P, Joseph, L, Yang, I, Brinker, A, Buckley, B, Kong, B, Guo, GL. Characterization of individual bile acids in vivo utilizing a novel low bile acid mouse model. Toxicol Sci. 2024;199 (2):316-331. PubMed PMID:38526215 PubMed Central PMC12104498.
Laskin, JD, Ozkuyumcu, K, Zhou, P, Croutch, CR, Heck, DE, Laskin, DL, Joseph, LB. Skin Models Used to Define Mechanisms of Action of Sulfur Mustard. Disaster Med Public Health Prep. 2023;17 :e551. PubMed PMID:37849329 PubMed Central PMC11420828.
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